[HTML][HTML] Predicting drug response and synergy using a deep learning model of human cancer cells

BM Kuenzi, J Park, SH Fong, KS Sanchez, J Lee… - Cancer cell, 2020 - cell.com
… DrugCell predictions are accurate in cell lines and also stratify clinical outcomes. Analysis of
… synergistic drug combinations, which we validate systematically by combinatorial CRISPR, …

oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data

D Maeser, RF Gruener, RS Huang - Briefings in bioinformatics, 2021 - academic.oup.com
… of cancer cell lines. These PCs were then included as covariates in a regression model for
drug sensitivitydrug response modeling in cancer: a systematic analysis with FORESEE …

Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens

P Larsson, H Engqvist, J Biermann… - Scientific reports, 2020 - nature.com
… IC50 values for (a–d) bortezomib- and (e–h) cisplatin-treated MCF7, HCC38, MCF-10A,
and MDA-MB-436 breast cancer cells generated in the present study and pharmacoDB 42 …

Machine learning approaches to drug response prediction: challenges and recent progress

G Adam, L Rampášek, Z Safikhani, P Smirnov… - NPJ precision …, 2020 - nature.com
Resistance to monotherapy While drug response prediction can help pick an optimal …
molecular characteristics of the cancer cells, tumors often exhibit drug resistance over the course of …

Improving drug response prediction by integrating multiple data sources: matrix factorization, kernel and network-based approaches

B Güvenç Paltun, H Mamitsuka… - Briefings in …, 2021 - academic.oup.com
… of cancer cell lines at the … cancer types by measuring drug responses [1]. As the amount of
data increases, the precise computational prediction of the drug sensitivity of cancer cell lines …

[HTML][HTML] Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery

Y Zou, J Xie, S Zheng, W Liu, Y Tang, W Tian… - International Journal of …, 2022 - Elsevier
… ideal predictive model for the progression and drug sensitivity of postoperative TNBC patients.
Diverse programmed cell death (PCD) patterns play an important role in tumortumor cells

Artificial intelligence in gastric cancer: a systematic review

P Jin, X Ji, W Kang, Y Li, H Liu, F Ma, S Ma… - Journal of cancer …, 2020 - Springer
… of AI-assisted methods, its main use in gastric cancer is for early detection, treatment guidance,
and prognosis prediction, which was systematically explored in the present … Methods

A systematic review of artificial intelligence techniques in cancer prediction and diagnosis

Y Kumar, S Gupta, R Singla, YC Hu - Archives of Computational Methods …, 2022 - Springer
… Radiation treatment: Radiation therapy kills the cancerous cells or slows down the growth
of cancerous cells by damaging their DNA. Medical experts often recommend this treatment to …

Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients

JH Kong, H Lee, D Kim, SK Han, D Ha, K Shin… - Nature …, 2020 - nature.com
… This work presents a method to predict cancer patient drug … , this work presents the first
systematic framework to leverage … cancer cell transcriptomic signatures associated with drug

[HTML][HTML] Effective drug combinations in breast, colon and pancreatic cancer cells

P Jaaks, EA Coker, DJ Vis, O Edwards, EF Carpenter… - Nature, 2022 - nature.com
… However, our ability to predict effective combinations is limited 4 . … To systematically identify
active drug combinations, we used the Genomics of Drug Sensitivity in Cancer (GDSC) cell