The RTS, S malaria vaccine: Current impact and foundation for the future

JG Beeson, L Kurtovic, C Valim, KP Asante… - Science Translational …, 2022 - science.org
… Obtaining an effective malaria vaccine has … a malaria vaccine called RTS,S for widespread
use in young children was an important milestone. RTS,S is a virus-like particle (VLP) vaccine

Implementation strategies for the introduction of the RTS, S/AS01 (RTS, S) malaria vaccine in countries with areas of highly seasonal transmission: workshop meeting …

CS Merle - Malaria journal, 2023 - Springer
… Programmes on Immunization (EPI) and National Malaria Control … RTS,S is the first malaria
vaccine to be recommended by the … pilot implementation of the vaccine in Ghana, Kenya and …

Multifunctional antibodies are induced by the RTS, S malaria vaccine and associated with protection in a phase 1/2a trial

L Kurtovic, T Atre, G Feng, BD Wines… - The Journal of …, 2021 - academic.oup.com
RTS,S is the leading malaria vaccine candidate but only confers partial efficacy against malaria
… may be a strategy to improve the protective efficacy of RTS,S or other malaria vaccines. …

Acceptance, availability, and feasibility of RTS, S/AS01 malaria vaccine: a review

…, A Nadeem, W Bilal, F Ansar, S Saleem… - Immunity …, 2023 - Wiley Online Library
… It was suggested that the RTS, S malaria vaccine be used extensively by the World Health
Organization on October 6, 2021. The successful pilot program testing the malaria vaccine in …

RTS, S/AS01 malaria vaccine—proven safe and effective?

A Björkman, CS Benn, P Aaby… - The Lancet Infectious …, 2023 - thelancet.com
… WHO recommended that the RTS,S malaria vaccine, with its … malaria transmission. The
evidence base included phase 3 trials in seven African countries and an ongoing malaria vaccine

Induction, decay, and determinants of functional antibodies following vaccination with the RTS, S malaria vaccine in young children

G Feng, L Kurtovic, PA Agius, EH Aitken, J Sacarlal… - BMC medicine, 2022 - Springer
RTS,S is the first malaria vaccine recommended for implementation among young children
… However, vaccine efficacy is modest and short-lived. Antibodies play the major role in vaccine

Estimated impact of RTS, S/AS01 malaria vaccine allocation strategies in sub-Saharan Africa: a modelling study

AB Hogan, P Winskill, AC Ghani - PLoS Medicine, 2020 - journals.plos.org
… falciparum malaria transmission to estimate the impact of introducing the RTS,S malaria
vaccine across Africa [19,20]. The model tracks the transmission of the parasite between …

A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naive …

JE Moon, C Ockenhouse, JA Regules… - The Journal of …, 2020 - academic.oup.com
… help achieve malaria elimination [1, 2]. To date, RTS,S/AS01 is the only malaria vaccine to
… III evaluation that demonstrated moderate vaccine efficacy (VE) against malaria [3–5]. The …

RTS,S/AS01 malaria vaccine (Mosquirix®): a profile of its use

YY Syed - Drugs & Therapy Perspectives, 2022 - Springer
RTS,S/AS01 (Mosquirix ® ) is a vaccine against malaria caused by Plasmodium falciparum.
… , RTS,S/AS01 showed vaccine efficacy against clinical malaria, severe malaria and malaria

Mosquirix™ RTS, S/AS01 vaccine development, immunogenicity, and efficacy

AY Nadeem, A Shehzad, SU Islam, EA Al-Suhaimi… - Vaccines, 2022 - mdpi.com
… on Immunization (SAGE) and the Malaria Policy Advisory Group (MPAC) evaluated Phase III
clinical results for the RTS, S malarial vaccine … with the RTS, S/AS01 vaccine utilizing a four-…