The role and activity of SWI/SNF chromatin remodelers

T Bieluszewski, S Prakash, T Roulé… - Annual Review of Plant …, 2023 - annualreviews.org
… with the SANT domains of SWI3 homologs, anchor the ATPase … findings indicate that SWI/SNF
CRCs are required for both … remodeling and enhancer accessibility rely on SWI/SNF CRC …

Mechanism of action of the SWI/SNF family complexes

K Chen, J Yuan, Y Sia, Z Chen - Nucleus, 2023 - Taylor & Francis
… around the arginine anchor region of the SnAc domain. (d) … the nucleosome remodeling
activity of SWI/SNF and RSC in … required diversity and sensitivity in response to the histone

SWI/SNF chromatin remodelers: structural, functional and mechanistic implications

A Singh, SB Modak, MM Chaturvedi… - Cell Biochemistry and …, 2023 - Springer
… , recombination and repair etc. require the transition of the … partially purified SWI/SNF-like
remodeling complex (SLC) … Snf5/Swi3/Snf2 HSA and anchor domain interactions), but also …

The AT-hook is an evolutionarily conserved auto-regulatory domain of SWI/SNF required for cell lineage priming

D Saha, S Hailu, A Hada, J Lee, J Luo… - Nature …, 2023 - nature.com
… modifiers and generally thought to help anchor them to DNA. We … the nucleosome remodeling
activity of WT and ΔAT SWI/SNF … laevis histones. In order to examine a single round of …

The mechanisms of action of chromatin remodelers and implications in development and disease

RK Sahu, S Singh, RS Tomar - Biochemical Pharmacology, 2020 - Elsevier
… site and histone-specific, but they lack DNA binding domain; hence they require additional
… Mutations in SWI/SNF complex is more prominent than other remodelling complexes, and it …

A unifying mechanism of DNA translocation underlying chromatin remodeling

L Yan, Z Chen - Trends in biochemical sciences, 2020 - cell.com
… To start to tease these mechanisms apart it was necessary to … (the motor subunit of the
SWI/SNF complex in yeast) and ISWI… tracking subdomain of the remodeler anchors the enzyme at …

Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome

FR Wagner, C Dienemann, H Wang, A Stützer… - Nature, 2020 - nature.com
… Chromatin-remodelling complexes of the SWI/SNF family function … The SnAC domain in the
SWI/SNF homologue Snf2 is … acts as a histone anchor that is required for nucleosome sliding …

Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14

P Enríquez, K Krajewski, BD Strahl, SB Rothbart… - Journal of Biological …, 2021 - ASBMB
domains, less is known about their function within chromatin complexes. SWI/SNF
chromatin-remodeling … Mutations in SWI/SNF subunits have been implicated in many cancers. …

Sophisticated conversations between chromatin and chromatin remodelers, and dissonances in cancer

CR Clapier - International Journal of Molecular Sciences, 2021 - mdpi.com
SWI/SNF accessory subunits, and future work will need to … increase their anchoring
contacts with the histones in order to … remodeling activities of yeast RSC and SWI/SNF [100,146]. …

The role of SWI/SNF chromatin remodelers in the repair of DNA double strand breaks and cancer therapy

M Sadek, A Sheth, G Zimmerman, E Hays… - Frontiers in Cell and …, 2022 - frontiersin.org
… the role of SWI/SNF chromatin remodeling complexes in … the ATPase domain of BRM and
BRG1 are required for their … is likely responsible for anchoring the SWI/SNF complex at the DSB…