[PDF][PDF] A single-cell atlas of chromatin accessibility in the human genome

K Zhang, JD Hocker, M Miller, X Hou, J Chiou… - Cell, 2021 - cell.com
human cell types To identify accessible chromatin regions in each of the 111 cell types, we
aggregated chromatin accessibility … We then merged these accessible chromatin regions to …

ATACdb: a comprehensive human chromatin accessibility database

F Wang, X Bai, Y Wang, Y Jiang, B Ai… - Nucleic Acids …, 2021 - academic.oup.com
… , users can obtain all accessible chromatin regions bound by … also submit a gene name,
and accessible chromatin regions … the accessible chromatin regions and associated genes, …

[HTML][HTML] Landscape of cohesin-mediated chromatin loops in the human genome

F Grubert, R Srivas, DV Spacek, M Kasowski… - Nature, 2020 - nature.com
… The development of high-throughput chromatin conformation assays (for example, Hi-C 1 …
3D organization of the human genome and how it influences gene regulation. Topologically …

Chromatin accessibility profiling methods

L Minnoye, GK Marinov, T Krausgruber, L Pan… - Nature Reviews …, 2021 - nature.com
… profiling methods may serve as an analytic foundation to identify regulatory regions, it is
reported that often less than 50% of accessible regions in human DNA are active as enhancers …

A human cell atlas of fetal chromatin accessibility

S Domcke, AJ Hill, RM Daza, J Cao, DR O'Day… - Science, 2020 - science.org
… regions that we identified spans 17% of the human genome, which is in line with recent
bulk DNase-seq profiles from fetal tissues (91). Most of these ~1 million elements are cell type–…

Chromatin accessibility: methods, mechanisms, and biological insights

AR Mansisidor, VI Risca - Nucleus, 2022 - Taylor & Francis
… Here, we review the ongoing development of accessibility … the accessibility landscape,
and we detail the many important biological functions that are linked to chromatin accessibility. …

[HTML][HTML] Genome-wide chromatin accessibility is restricted by ANP32E

KE Murphy, FW Meng, CE Makowski… - Nature …, 2020 - nature.com
… Z with highly accessible chromatin, we next sought to functionally test whether increasing …
-Accessible Chromatin combined with high-throughput sequencing (ATAC-Seq), and gene

Epigenetic patterns in a complete human genome

A Gershman, MEG Sauria, X Guitart, MR Vollger… - Science, 2022 - science.org
… Here, we present an epigenetic annotation of the human genome in which we explore …
duplicated genes, and a diverse collection of repeat classes, including human centromeres. …

[HTML][HTML] Differential chromatin accessibility landscape reveals structural and functional features of the allopolyploid wheat chromosomes

KW Jordan, F He, MF de Soto, A Akhunova, E Akhunov - Genome biology, 2020 - Springer
… with chromatin accessibility in … accessible chromatin explain a higher proportion of genetic
variance for a number of agronomic traits than SNPs located within more closed chromatin

Chromatin accessibility dynamics in a model of human forebrain development

AE Trevino, N Sinnott-Armstrong, J Andersen, SJ Yoon… - Science, 2020 - science.org
… To chart the regulatory activity underlying these events, we generated a map of accessible
chromatin in human three-dimensional forebrain organoids. To capture corticogenesis, we …