… Mutations within chromatin remodelling complexes represent another class of cancer-related
lesions, which are estimated to affect about 10–20% of all cancers 24 . Similar to …

… transcriptional activation and is instead likely to have a more complex role in chromatin
regulation … the uncoupling of H3K4me3 from transcriptional regulation in MLL2-mutant ESCs (Fig. …

… -transcriptional events place RNA processing factors in close contact with chromatin during
transcription … processing factors to conversely regulate transcription. Despite the observations …

… This includes changes in histone and DNA modification and localised chromatin compaction.
Further elucidating the complex, co-ordinated mechanisms of chromatin regulation in low …

… advances in uncovering the mechanisms that regulate chromatin modifications. Here, we …
in chromatin biology ranging from cooperativity and multivalent interactions to regulatory …

… gene body, suggesting that transcription does not initiate widely … transcription-associated
histone modifications and nascent transcripts at both transcription start sites and cis-regulatory …

… While it was previously thought that the transcriptional activity is associated with more open
and dynamic chromatin … more nuanced role of transcription in chromatin dynamics: dynamic …

… Figure 4 illustrates our vision of gene transcription regulation data and its integrative
analysis and representation within the GTRD framework. We also plan to integrate data on …

… an unexpected complexity in chromatin-dependent regulation of ncRNA gene transcription
by the … Emerging common features, like the heterogeneity of chromatin states within ncRNA …

… In contrast to H3K36me3 found over gene bodies, H3K36me2 is abundant around TSSs
and in intergenic regions, with lower levels throughout transcribed regions. Both H3K36me2 …