… The Pol II C-terminal domain contains low complexity amino acid sequences, which cause
Pol II to phase separate within transcriptional condensates [26]. The Pol II C-terminal domain …

… lamins regulate transcription at associated-promoters and long-range chromatin interactions
… LADs, focusing on transcriptional regulation and chromatin organization in Drosophila and …

DNA can determine where and when genes are expressed, but the full set of sequence
determinants that control gene expression is unknown. Here, we measured the transcriptional …

… model of enhancer-mediated regulation that can exhibit hypersensitivity through bistability
and hysteresis. Consistent with recent experiments, this regulation does not exhibit strong …

… through 3D chromatin … complex dynamics of cis-regulations involving multiple layers,
we conceptually decomposed the gene regulation into a three-layered hierarchy: (1) cis-regulation …

… interactions between transcription factors and chromatin, which is … Some transcription factors
binding to chromatin regulatory … , while others require the assistance of open chromatin and …

Collaboration of transcription factors (TFs) and their recognition motifs in DNA is the result of
coevolution and forms the basis of gene regulation. However, the way how these short …

… transcription dynamics of considering chromatin remodeling as the main material basis of
gene expression regulation… If the chromatin structure is the main driver of gene co-regulation, …

… other model systems when relevant. We begin by discussing the molecular regulation of
bivalency… to regulation of bivalent chromatin in mammalian cells and especially in mouse ESCs. …

… chromatin states on enhancer function. We also discuss how … chromatin may play a role in
novel theories of transcription such as the role of biomolecular condensates in gene regulation…