Physical nature of chromatin in the nucleus

K Maeshima, S Iida, S Tamura - … Harbor perspectives in …, 2021 - cshperspectives.cshlp.org
chromatin in living cells have been developed over the past 10 years. Our view on chromatin
Chromatin forms numerous compact dynamic domains that act as functional units of the …

Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

L Bideyan, W Fan… - Proceedings of the …, 2022 - National Acad Sciences
… of genome-wide chromatin accessibility, gene expression, and transcription factor binding.
We reveal distinct mechanisms of LXR transcriptional regulation of both metabolic and …

Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver

M Bozukova, C Nikopoulou… - Molecular Systems …, 2022 - embopress.org
During transcription initiation, Pol II is recruited to the accessible promoter region through the
concerted action of general transcription … formation of the preinitiation complex (PIC), before …

[HTML][HTML] Effects of forces on chromatin

K Amar, F Wei, J Chen, N Wang - APL bioengineering, 2021 - pubs.aip.org
… It is well known that soluble transcription factors regulate gene … state of chromatin often
limits access of transcription factors … regulate chromatin domains for local transcription control. …

[HTML][HTML] Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation

AL Hughes, JR Kelley, RJ Klose - … Biophysica Acta (BBA)-Gene Regulatory …, 2020 - Elsevier
… factors (TFs), which shape how the transcriptional machinery engages with gene promoters
… initiate transcription. However, in eukaryotes, the chromatin template on which transcription

[HTML][HTML] The solid and liquid states of chromatin

JC Hansen, K Maeshima, MJ Hendzel - Epigenetics & Chromatin, 2021 - Springer
… of arrays were transcribed by Pol II … chromatin is a bona fide substrate for in vitro transcription.
Their results also suggested that promoter sequences within the aggregated chromatin

[HTML][HTML] Multiple roles of H2A. Z in regulating promoter chromatin architecture in human cells

L Cole, S Kurscheid, M Nekrasov… - Nature …, 2021 - nature.com
… establish the chromatin regulatory framework for a promoter. It is important to add that while
our … that many other types of promoter chromatin arrangements exist that differ in more subtle …

MYC protein interactors in gene transcription and cancer

C Lourenco, D Resetca, C Redel, P Lin… - Nature Reviews …, 2021 - nature.com
… However, the importance of the following interactions during transcription in cancer provides
the rationale for further study and the development of anti-MYC therapeutics targeting MYC …

Decoding the function of bivalent chromatin in development and cancer

D Kumar, S Cinghu, AJ Oldfield, P Yang… - Genome …, 2021 - genome.cshlp.org
… we sought to investigate the transcriptional fate of bivalent genes during early embryonic
development … Using the data that we previously generated from chromatin immunoprecipitation …

[HTML][HTML] Transcription control of liver development

EC Tachmatzidi, O Galanopoulou, I Talianidis - Cells, 2021 - mdpi.com
… This study showed that FoxA1 has a significant role in the transcriptional control of genes
regulating glucose homeostasis [22]. Mouse models lacking FoxA2 are unable to form a …