… The β-lactamase genes (bla genes) encoding subclass B1 metallo-β-lactamases are
largely plasmid-borne and are of greater clinical relevance compared with metallo-β-lactamase …

… Here we review the classification, structures, substrate profiles, and inhibition mechanisms
of MBLs, highlighting current clinical problems due to MBL-mediated resistance and progress …

… Delhi metallo-β-lactamase-1 (NDM-1), imipenemase-1 (IMP-1) and Verona integron-encoded
metallo-β-lactamase-2 … Cephalosporins inhibit human metallo β-lactamase fold DNA repair …

… Because the first solved structure of this superfamily was BcII, the metallo-β-lactamase from
B. cereus by Carfi, Dideberg, and co-workers, (217) it is known as the MBL fold. The large …

… -lactam antibiotics, and no clinically useful inhibitors against them have yet been approved.
… mechanism with similar reaction species. Here, we describe a number of MBL inhibitors that …

… -spectrum MBLs and SBLs inhibitors to combat rapidly growing β… inhibitor chemotypes and
their inhibition mechanisms. The common pharmacophore features of MBL and SBL inhibitors …

… Metallo-β-lactamase (MBL) enzymes are a particular concern and are increasingly …
Nonboronate inhibitors face toxicity issues, particularly if they interact with other metalloenzymes or …

… the metallo-β-lactamase, while the rest are serine β-lactamases. The clinical use of β-lactamase
inhibitors began … researchers address root issues and develop more effective inhibitors. …

… In the meantime, to ensure continued support, we are displaying the site without styles and
… MBL inhibition is challenging because of the structural diversity in MBL active sites (Fig. 1b) …

… encountered and solved a range of issues. For example, in the MBL inhibitor series we were
able to … campaign resulting in the discovery of the metallo-β-lactamase inhibitor ANT2681. …