Pathway paradigms revealed from the genetics of inflammatory bowel disease

DB Graham, RJ Xavier - Nature, 2020 - nature.com
… transformative approaches in human genetics and functional genomics. Here we describe
IBD as a model disease in the context of leveraging human genetics to dissect interactions in …

[HTML][HTML] Genetic and epigenetic characteristics of inflammatory bowel Disease–Associated colorectal cancer

K Rajamäki, A Taira, R Katainen, N Välimäki… - Gastroenterology, 2021 - Elsevier
Inflammatory bowel disease increases the risk of colorectal cancer and the tumors developing
in patients may be genetically and epigenetically distinct compared to sporadic tumors. …

[HTML][HTML] Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models

E Mizoguchi, D Low, Y Ezaki, T Okada - Intestinal research, 2020 - ncbi.nlm.nih.gov
… The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated…
IBD, Crohn’s disease (CD) and ulcerative colitis (UC), and both disorders affect individuals …

Very early onset inflammatory bowel disease: a clinical approach with a focus on the role of genetics and underlying immune deficiencies

J Ouahed, E Spencer, D Kotlarz… - Inflammatory bowel …, 2020 - academic.oup.com
… Very early onset inflammatory bowel disease (VEO-IBD) is defined as IBD presenting before
… In addition, patients with VEO-IBD have a higher incidence of inflammatory bowel disease

Inflammatory bowel disease and Parkinson's disease: common pathophysiological links

HS Lee, E Lobbestael, S Vermeire, J Sabino, I Cleynen - Gut, 2021 - gut.bmj.com
… the concept of the ‘gut–brain axis’. Moreover, recent population-based studies have shown
that inflammatory bowel disease might increase the risk of Parkinson's disease. Although the …

[HTML][HTML] Evidence-based clinical practice guidelines for inflammatory bowel disease 2020

H Nakase, M Uchino, S Shinzaki, M Matsuura… - Journal of …, 2021 - Springer
Inflammatory bowel disease (IBD) is a general term for chronic or remitting/… inflammatory
diseases of the intestinal tract and generally refers to ulcerative colitis (UC) and Crohn’s disease

[HTML][HTML] The gut microbiota in inflammatory bowel disease

P Qiu, T Ishimoto, L Fu, J Zhang, Z Zhang… - Frontiers in cellular and …, 2022 - frontiersin.org
… Epidemiological surveys indicate that the incidence of inflammatory bowel disease (IBD)
is increasing rapidly with the continuous growth of the economy. A large number of studies …

The microbiome in inflammatory bowel diseases: from pathogenesis to therapy

S Liu, W Zhao, P Lan, X Mou - Protein & cell, 2021 - academic.oup.com
Inflammatory bowel disease (IBD) has become a global disease with accelerating incidence
worldwide in the 21st century while its accurate etiology remains unclear. In the past decade…

Inflammatory bowel diseases (IBD) and the microbiome—searching the crime scene for clues

M Lee, EB Chang - Gastroenterology, 2021 - Elsevier
… , genetics, and gut microbes to the development of disease. Here, we present a selective
review and commentary on the microbial basis … of inflammatory bowel diseases. This framework …

Colorectal cancer in inflammatory bowel disease: mechanisms and management

SC Shah, SH Itzkowitz - Gastroenterology, 2022 - Elsevier
… Patients with inflammatory bowel disease (IBD) are at increased risk of developing colorectal
cancer (CRC), despite decreases in CRC incidence in recent years. Chronic inflammation