… , clinical utility that aims for risk prediction and/or diagnostic assistance based on the individual
“variants” is difficult to use. … and possibilities for the clinical utility of PRS in psychiatry. …

… responsible clinical … of polygenic risk scores and current evidence for their efficacy and
safety. We discuss the implementation of these scores in clinical medicine for uses including risk …

… areas assessing the predictive ability of PRS, we discuss below the strongest evidence
for potential clinical utility, with special reference to our research area, psychiatric disorders [46]. …

… Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of
individuals to diseases. All individuals have DNA risk … currently may have clinical utility for some …

… polygenic inheritance is not appropriate for clinical use and should not be offered as
direct-to-consumer testing at this time. Two independent ACMG documents will be addressing this …

… meaningful risk prediction … risk variants into individualized disease risk prediction,
prognostication, and may enable targeted treatments. In this context, we review the clinical utility of …

… been directed toward the development of a risk calculator to … their clinical utility, albeit only
directly affecting clinical decision… We suggest that clinical decisions about high risk associated …

… for a specific disease or trait, and recent studies have shown that they may have clinical utility
… that outweigh risks, and where effort is taken towards a goal of equitable benefit for all. The …

… To our knowledge, there are currently no germline PRSs in clinical use; however, multiple
… While there is currently no clinical utility of genetic risk scores in AD, PRSs could potentially …

… Clinical use of polygenic risk scores (PRS) will look very different to the more familiar
monogenic testing. Here we argue that despite these differences, most of the ethical, legal, and …