… The Oncosimulator is a top-down discrete entity-discrete event model for multiscale
cancer modeling, that represents the tumor in silico as a 3D matrix of voxels and utilizes the «…

… clinical, treatment, imaging, and genomic data with models, … applied in patients with
nephroblastoma or Wilms tumor (WT) … of a patient are utilized to adjust the initial levels of the …

… , the specific application of the model to neuroblastoma cancer, and the … model represents
a promising step forward towards … in childhood cancer to better tailor treatment, adjust dosage …

… Neuroblastoma is a complex and aggressive type of cancer that affects children. Current
treatments … It could certainly be adapted as drug resistance is a critical issue in positive patient …

… workflow, are quantitatively adapted to clinical settings since … a four-dimensional
nephroblastoma treatment model and evaluated its employment in clinical decisions making. …

… Moreover, notable improvements in colorectal cancer treatments with in silico studies and
the enhanced selectivity on specific macromolecular targets were discussed. Besides, the …

… models of individual drug response and tailor treatment accordingly, we will need to develop
mathematical models … in the application of systems biology towards precision oncology. …

… in vitro models. Commercial cell … treatment response (11–14). We previously developed
multi-lineage patient-derived cell cultures (PDCs) of neuroblastoma from pre- and post-treatment …

… be a novel promising antitumor candidate for GMB treatment. … It was found that TMZ
demonstrated a low cytotoxicity toward … by human breast and prostate cancer cells. Hence, the …

… An increasing number of cancer patients are treated with proton therapy. Nevertheless, …
endpoints and suggest models from other disciplines for adaptation to biomedical proton …