Background Preliminary data suggested that fat embolism could explain the importance of
visceral obesity as a critical determinant of coronavirus disease-2019 (COVID-19). Methods
We performed a comprehensive histomorphologic analysis of autoptic visceral adipose
tissue (VAT), lungs and livers of 19 subjects with COVID-19 (COVID-19+), and 23 people
without COVID-19 (controls). Human adipocytes (hMADS) infected with SARS-CoV-2 were
also studied. Results Although there were no between-group differences in body-mass …

Background Visceral obesity is a critical determinant of severe coronavirus disease-2019
(COVID-19). Methods: In this study, we performed a comprehensive histomorphologic
analysis of autoptic visceral adipose tissues (VAT), lungs and livers of 19 COVID-19 and 23
non-COVID-19 subjects. Results Although there were no between-groups differences in
body-mass-index and adipocytes size, higher prevalence of CD68+ macrophages in COVID-
19 subjects' VAT was detected (p= 0.005) and accompanied by crown-like structures …