The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease

M Colom-Cadena, T Spires-Jones, H Zetterberg… - Alzheimer's research & …, 2020 - Springer
Background Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s
disease (AD) and lead to reduced cognitive function. The goal of this review is to address …

Accelerated functional brain aging in pre-clinical familial Alzheimer's disease

J Gonneaud, AT Baria, A Pichet Binette… - Nature …, 2021 - nature.com
… The dementia of AD is characterized by progressive cognitive decline that becomes
sufficient to impair activities of daily living 21 . Prior work has shown that brain changes …

Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease

X Wang, W Huang, L Su, Y Xing, F Jessen… - Molecular …, 2020 - Springer
Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the
Alzheimer’s disease (AD) continuum. Investigating populations with SCD is important for …

[HTML][HTML] Subclinical epileptiform activity accelerates the progression of Alzheimer's disease: A long-term EEG study

AA Horvath, A Papp, J Zsuffa, A Szucs, J Luckl… - Clinical …, 2021 - Elsevier
activity occurs in half of Alzheimer patients who have never suffered epileptic seizures.
Alzheimer patients with subclinical epileptiform activity … of Alzheimer's disease which might serve …

The sleep side of aging and Alzheimer's disease

SM Romanella, D Roe, E Tatti, D Cappon, R Paciorek… - Sleep medicine, 2021 - Elsevier
Alzheimer’s Disease (AD). AD night time is characterized by a gradual decrease in slow-wave
activity … -related drop in brain plasticity and a lack of cognitive activity would account for a …

Lipid profiling of Alzheimer's disease brain highlights enrichment in glycerol (phospho) lipid, and sphingolipid metabolism

S Akyol, Z Ugur, A Yilmaz, I Ustun, SKK Gorti, K Oh… - Cells, 2021 - mdpi.com
… cholesterol levels in hippocampal neurons [30], while γ- and β-secretase activities were
promoted due to elevated cholesterol levels in AD brains [31]. Taken together, in the AD affected …

Altered metabolism in Alzheimer disease brain: role of oxidative stress

NG Rummel, DA Butterfield - Antioxidants & Redox Signaling, 2022 - liebertpub.com
diseases. Aging is the greatest risk factor of neurodegenerative diseases, the most prominent
being Alzheimer disease (… Cytochrome c oxidase shows reduced activity in the AD brain (…

The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

E Barone, F Di Domenico, M Perluigi… - Free Radical Biology and …, 2021 - Elsevier
… the adult brain, and at least 25% of consumed glucose is used to drive basal brain activities
[7]. Glucose metabolism sustains the physiological functions of the brain through glycolysis …

[Retracted] Diagnosis of Alzheimer Disease Using 2D MRI Slices by Convolutional Neural Network

FEK Al-Khuzaie, O Bayat… - Applied Bionics and …, 2021 - Wiley Online Library
… different brain activities, and the different brain activities display different functional brain
images … a significant role in identifying different activities of the brain. Recently, many methods of …

Early diagnosis of Alzheimer's disease: the role of biomarkers including advanced EEG signal analysis. Report from the IFCN-sponsored panel of experts

PM Rossini, R Di Iorio, F Vecchio, M Anfossi… - Clinical …, 2020 - Elsevier
… of disease, although not able to modify its course, helps to maintain personal autonomy in
daily activities and significantly reduces the total costs of diseaseAlzheimer's disease (AD) is …