The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer's disease

G Tondo, L Iaccarino, SP Caminiti, L Presotto… - Alzheimer's research & …, 2020 - Springer
… into the early changes in synaptic activity, by showing specific metabolic disconnections in
… The relationship between microglia activity and glucose metabolism in AD was investigated …

A deep convolutional neural network based computer aided diagnosis system for the prediction of Alzheimer's disease in MRI images

V Sathiyamoorthi, AK Ilavarasi, K Murugeswari… - Measurement, 2021 - Elsevier
… However, they did not shed light on the interaction of the inner brain region correlated
with brain activity or fascinating illness. Human brain is, in essence, anatomically a rather …

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

V Hook, M Yoon, C Mosier, G Ito, S Podvin… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… cathepsin B protein and activity in CSF are elevated compared to controls [38]. Furthermore,
cathepsin B activity in CSF is elevated in the inflammatory neurological diseases of Guillain-…

Neuroprotective natural products for Alzheimer's disease

X Chen, J Drew, W Berney, W Lei - Cells, 2021 - mdpi.com
… in the pharmaceutical industry for their neuroprotective activity, targeting different pathological
… from different sources that have demonstrated neuroprotective activity in preclinical and/or …

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease

S Dujardin, C Commins, A Lathuiliere, P Beerepoot… - Nature medicine, 2020 - nature.com
… We used these antibodies to deplete seeding activity from the brain extracts of 15 of 32
participants for whom material was available. First, antibodies coupled to magnetic beads were …

Exposure to gamma tACS in Alzheimer's disease: A randomized, double-blind, sham-controlled, crossover, pilot study

A Benussi, V Cantoni, MS Cotelli, M Cotelli, C Brattini… - Brain Stimulation, 2021 - Elsevier
activity, resulting in a significant improvement of cognitive performances [[7], [8], [9]]. In
humans, commonly applied external modalities to entrain brain activityactivity in specific brain

Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …

G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
Alzheimer disease) and LOAD (late-onset Alzheimer disease). … activity, consequently
preventing inflammation in the brain … Aβ is a toxic peptide whose presence in post mortem brains

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

IW Weidling, RH Swerdlow - Experimental neurology, 2020 - Elsevier
… Reduced cytochrome oxidase (COX) activity has consistently been observed across numerous
tissues. Initial studies describe decreased COX activity in AD patient brains and platelets. …

Insulin mediated novel therapies for the treatment of Alzheimer's disease

SK Dubey, KK Lakshmi, KV Krishna, M Agrawal… - Life sciences, 2020 - Elsevier
… Apart from regulating the glucose metabolism in the brain, … activities of receptors like GABA
10 and glutamate [12,24,25]. Hence, it is to be proved that insulin is essential for brain activity

New insights into the pathogenesis of Alzheimer's disease

L Fan, C Mao, X Hu, S Zhang, Z Yang, Z Hu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …