… brain during the disease process, but they are also released in normal brains throughout our
lives during synaptic activity … concentrations of Aβ in the brain can regulate synaptic plasticity…

… Alzheimer’s disease. Senescent cells accumulated in the aging and Alzheimer’s disease
brains … At the neural circuitry level, increasing neuronal activity at one brain region can lead to …

… with late-onset Alzheimer’s disease that exhibit higher γ-secretase activity. The amount of …
with γ-secretase activity in samples from patients with late-onset Alzheimer’s disease. These …

… brain activity in various neurodegenerative diseases. As an important participant in brain
compensation for excessive glucose utilization, brain … functions to guarantee brain energy and …

… proteins specific to the brain and disrupts their structure and functionality. Such an escalation
can be detrimental to the metabolic proteins of the brain. This activity of Aβ suggests the …

… activity in mammalian cells 52 . In a postmortem human brain study, it was shown that human
brain-… , Aph-1, and Pen-2 and that these are associated with γ-secretase activity 55 . The …

… in the brain. For fMRI, the alteration in blood flow and blood oxygen concentration measurement
shows the brain’s metabolic activities [16]. The amount of shrinkage in brain sub-regions…

… activities and POLβ expression were also observed in AD brains (n = 10) in comparison to
age-matched control brains (n … Downregulation of mitochondrial BER activity in AD brain was …

… (AD) is a progressive neurodegenerative disorder in which electrical activities of the brain
… of multichannel EEG signals from healthy and Alzheimer's disease (AD) subjects, which are …

… In AD trials, the most clinically significant (direct) endpoints are cognitive improvement and
rescued brain activity [85]. In addition to direct endpoints, the meeting of indirect endpoints …