… In AD trials, the most clinically significant (direct) endpoints are cognitive improvement and
rescued brain activity [85]. In addition to direct endpoints, the meeting of indirect endpoints …

… by the gut microbiota possess essential biological activities, including neuroprotection and
… and the brain. Studies have shown that some of these substances' activities result from …

… Alteration of the gut microbiota can induce changes in brain activity, which raise the
possibility of therapeutic manipulation of the microbiome in AD and other neurological disorders. …

Resting‐state fMRI (rs‐fMRI) detects functional connectivity (FC) abnormalities that occur in
the brains of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). FC …

… In the context of normal brain health, the endosomal–lysosomal network (ELN) and
autophagy are involved in memory and cognition, with local autophagy activity at synapses …

… of connectivity among brain regions affecting neural pathways and disrupting the functional
coherence of brain activities. The MCI and AD show abnormal regional brain activation as …

… Alzheimer’s disease (AD) brain remain incompletely understood. In this study, we analyzed
the proteomes of more than 1,000 brain … preserved across cohorts and brain regions. Nearly …

… . Work-related physical activity and the risk of dementia and Alzheimer's disease. Int J
Geriatr Psychiatry 2007;22:874–82.doi:10.1002/gps.1755 pmid:http://www.ncbi.nlm.nih.gov/…

… , 8-oxoG accumulation at the promoters of genes critical for brain function, and … activity
and downregulation of a similar gene set in the 5XFAD mouse model of Alzheimer’s disease. …

… Additionally, Al could hinder the antioxidant enzyme activities, changing brain … , where it
improves the AChE activity and thereby elevate the breakdown of ACh in the brain. As the same, …