AP-1 imprints a reversible transcriptional programme of senescent cells

RI Martínez-Zamudio, PF Roux, JANLF de Freitas… - Nature cell …, 2020 - nature.com
… 2d) and the differential impact of the TFs on RAS-OIS-associated enhancer activation as …
Pharmacological inhibition of TFs (see above for AP-1), signal transduction molecules, such …

[HTML][HTML] AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL

Z Wu, M Nicoll, RJ Ingham - Experimental hematology & oncology, 2021 - Springer
… death-ligand 1 (PD-L1) is also mediated by AP-1 transcription factors in cHL and ALK+
ALCL [114, 115]. PD-L1 is a ligand for the immune inhibitory receptor, program death-1 (PD-1), …

Differential effects of inhibitors of PTZ‐induced kindling on glutamate transporters and enzyme expression

N Taspinar, A Hacimuftuoglu, S Butuner… - Clinical and …, 2021 - Wiley Online Library
… , and z-axis from bregma) was AP −3 mm, ML +4 mm, and DV 1 mm, and the second location
was AP −3 mm, ML −4 mm, and DV 1 mm. Stainless steel screw electrodes were placed on …

Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

DC Mastellos, BGPP da Silva, BAL Fonseca… - Clinical …, 2020 - Elsevier
… Both inhibitors led to sustained inhibition of ex vivo AP-mediated complement hemolytic
activity (AP50) in COVID-19 patient sera (Fig. 5, C). While AMY-101 treatment resulted in …

Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1

C Xu, H Kleinschmidt, J Yang, EM Leith, J Johnson… - Molecular Cell, 2024 - cell.com
1) FOXA1 binding is strongly affected by co-binding transcription factors (TFs) AP-1 and CEBPB;
(2) FOXA1 and AP-1 … (4) AP-1 is partially responsible for differential binding of FOXA1 in …

[HTML][HTML] TGFβ and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

A Sundqvist, E Vasilaki, O Voytyuk, Y Bai, M Morikawa… - Oncogene, 2020 - nature.com
differential effects and verify the specificity of the inhibitors, … inhibitors SB505124 and
LY364947 strongly inhibited the C-terminal phosphorylation of SMAD2 and SMAD3 induced after 1

Transcriptomic analysis of benign prostatic hyperplasia identifies critical pathways in prostatic overgrowth and 5‐alpha reductase inhibitor resistance

R Jin, CM Forbes, NL Miller, J Lafin, DW Strand… - The …, 2024 - Wiley Online Library
… .1.30.1) was used to detect differentialAP-1 has been implicated in the “memory of
inflammation,” allowing cells to rapidly respond to secondary stress event. Here we confirm that AP-1

Ginkgolide B suppresses TPA-induced metastatic potential in MCF-7 human breast cancer cells by inhibiting MAPK/AP-1 signaling

MG Lee, SG Lee, KS Nam - Biotechnology and Bioprocess Engineering, 2022 - Springer
… governed by the inhibition of MAPK/AP-1 signaling pathways … GKB inhibited the TPA-induced
nuclear translocation of AP-1inhibited the TPA-induced nuclear translocation of the AP-1

Effects of galectin-1 inhibitor OTX008 on oral squamous cell carcinoma cells in vitro and the role of AP-1 and the MAPK/ERK pathway

PFC Greer, A Rich, DE Coates - Archives of Oral Biology, 2022 - Elsevier
… To investigate the in vitro effects of inhibiting galectin-1 using the small-molecule inhibitor
OTX008 on oral squamous cell carcinoma (OSCC) cell lines and the role of the MAPK pathway…

[HTML][HTML] Differential synaptic input to external globus pallidus neuronal subpopulations in vivo

M Ketzef, G Silberberg - Neuron, 2021 - cell.com
inhibitory inputs during slow wave activity and responded to sensory stimulation with distinct
multiphasic patterns. Prototypic cells synaptically inhibited … potential (AP) firing (Figure 1G). …