Single cell dissection of epithelial-immune cellular interplay in acute kidney injury microenvironment

M Zhang, L Wu, Y Deng, F Peng, T Wang… - Frontiers in …, 2022 - frontiersin.org
cell populations was revealed, which may hide or skew signals of interest with specific cellular
identities and biologically-relevant mechanisms. Dissecting the … and develop new targeted …

Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencing

A Schumacher, MB Rookmaaker, JA Joles… - NPJ Regenerative …, 2021 - nature.com
… of kidney development based on such data, more diverse cell … in development, we suggest
that cells in developing kidneys may best be regarded as a continuum instead of distinct cell

Mapping the human kidney using single-cell genomics

F Schreibing, R Kramann - Nature Reviews Nephrology, 2022 - nature.com
… restriction during kidney development remain incomplete. … to dissect the genetic programs,
pathways and mechanisms of cellular crosstalk underlying physiological kidney development

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets

Z Miao, MS Balzer, Z Ma, H Liu, J Wu… - Nature …, 2021 - nature.com
cell multi-omics atlas reveals key chromatin remodeling events and gene expression dynamics
associated with kidney development… to dissect specific cell types in the developing kidney

How many cell types are in the kidney and what do they do?

MS Balzer, T Rohacs, K Susztak - Annual review of physiology, 2022 - annualreviews.org
… Our analysis of mouse kidney development indicated the expression of loop of Henle markers
such … Mass cytometry on healthy renal tissue enabled dissection of T cell and myeloid cell

3D mapping reveals a complex and transient interstitial matrix during murine kidney development

SN Lipp, KR Jacobson, DS Hains… - Journal of the …, 2021 - journals.lww.com
… provide an external scaffold for kidney cells. Current efforts have led … that integrates disparate
cells into a functional kidney. … in developing, homeostatic, and diseased tissues. ECM in the …

Renin cells, the kidney, and hypertension

MLS Sequeira-Lopez, RA Gomez - Circulation research, 2021 - Am Heart Assoc
… Distribution of renin-expressing cells during kidney development and in response to … , further
work is necessary to dissect how the TF Foxd1 controls guidance cues, cell number, and the …

[HTML][HTML] Vascular deficiencies in renal organoids and ex vivo kidney organogenesis

AR Ryan, AR England, CP Chaney, MA Cowdin… - Developmental …, 2021 - Elsevier
… organoids can develop a wide range of kidney cell types, as … that recapitulate normal kidney
development hold a tangible … Briefly, kidneys were dissected from embryonic day 17.5 (E17…

Targeted single-cell RNA-seq identifies minority cell types of kidney distal nephron

L Chen, CL Chou, MA Knepper - Journal of the American Society …, 2021 - journals.lww.com
… The cortical region of kidney tissue was then dissected and minced on ice, followed by …
during kidney development. Among DCT1 cells, we also identified a small population of cells that …

[PDF][PDF] Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

SE Howden, SB Wilson, E Groenewegen, L Starks… - Cell Stem Cell, 2021 - cell.com
cells to kidney cell types have significantly advanced our ability to study human kidney
development … Based on a careful dissection of gene expression within the UE and DN within the …