Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

L De Chiara, C Conte, R Semeraro… - Nature …, 2022 - nature.com
… conserved mechanism developed to permit a quick recovery of kidney function after damage
… To better dissect polyploid TC distribution in the various portions of the nephron, we then …

Multi-omics integration in the age of million single-cell data

Z Miao, BD Humphreys, AP McMahon… - Nature Reviews …, 2021 - nature.com
… single-cell transcriptome data to identify gene regulatory circuits involved in kidney development
14 , … One tool that uses this approach to dissect heterogeneity in joint transcriptome and …

The Pan-Immune Inflammation Value at Admission Predicts Postoperative in-hospital Mortality in Patients with Acute Type A Aortic Dissection

X Yu, Y Chen, Y Peng, L Chen, Y Lin - Journal of Inflammation …, 2024 - Taylor & Francis
… mortality in patients with ATAAD and develop measures to reduce postoperative mortality …
effects of high PIV on acute kidney injury. The four blood cells in PIV are obtained from …

The incidence, risk factors and in-hospital mortality of acute kidney injury in patients after surgery for acute type A aortic dissection: a single-center retrospective …

L Li, J Zhou, X Hao, W Zhang, D Yu, Y Xie, J Gu… - Frontiers in …, 2020 - frontiersin.org
… of CKD have a significantly higher risk for developing AKI after surgery for AAAD. From our
… In addition, the units of red blood cell transfusion in our study were higher in patients with …

Spatial transcriptional mapping of the human nephrogenic program

NO Lindström, R Sealfon, X Chen, RK Parvez… - Developmental cell, 2021 - cell.com
… an understanding of kidney development and disease and enhance efforts to generate new
… events or cell types. Although single-cell-omic approaches now facilitate the dissection and …

Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli

V Saxena, H Gao, S Arregui, A Zollman… - Nature …, 2021 - nature.com
… tubule perfused in vivo with bacteria expands on prior in vitro techniques like cell culture and
perfusion of dissected tubules. Here, we developed methodology to directly test in live mice …

Vascular endothelial cell development and diversity

E Trimm, K Red-Horse - Nature Reviews Cardiology, 2023 - nature.com
… of the brain form the blood–brain barrier (BBB) with tight intercellular junctions to restrict
transport, whereas glomerular capillary endothelial cells in the kidney are highly fenestrated to …

LncRNA H19 regulates smooth muscle cell functions and participates in the development of aortic dissection through sponging miR-193b-3p

M Ren, T Wang, X Wei, Y Wang, C Ouyang… - Bioscience …, 2021 - portlandpress.com
dissection (AD). Methods: The expressions of related genes in human aortic smooth muscle
cells (… The H19 and miR-193b-3p effects on the biological functions of tissues and cells were …

[HTML][HTML] Kidney tertiary lymphoid structures in lupus nephritis develop into large interconnected networks and resemble lymph nodes in gene signature

SE Dorraji, P Kanapathippillai, AMK Hovd… - The American Journal of …, 2020 - Elsevier
… during the development of murine LN and TLS. In conclusion, kidney TLS have a similar cell
… isolated from renal draining lymph nodes, kidney, and TLS dissected from kidney (n = 3). …

Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease

Y Xu, C Kuppe, J Perales-Patón, S Hayat, J Kranz… - Nature …, 2022 - nature.com
… of human kidney development and contain nonkidney cell types … human adult kidney have
been reported as cells outgrowing … The tissue was dissected and minced. The fragments were …