[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
molecular mechanisms driving diabetic kidney disease to help identify new therapies that
slow progression and reduce associated risks. Diabetic kidney … of molecular mechanisms that …

Inflammation in kidney repair: Mechanism and therapeutic potential

Y Fu, Y Xiang, H Li, A Chen, Z Dong - Pharmacology & therapeutics, 2022 - Elsevier
… During the recovery phase, several molecular mechanisms promote the proliferation and
survival of myofibroblasts as well as overproduction of extracellular matrix (ECM) by directing …

Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches

P Qu, L Li, Q Jin, D Liu, Y Qiao… - … of Molecular …, 2024 - spandidos-publications.com
… Podocyte dedifferentiation is regulated by a complex array of molecular mechanisms,
primarily involving signaling pathways, such as the Wnt/β‑catenin, Notch and TGF‑β/Smad …

Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives

Y Wang, M Jin, CK Cheng, Q Li - Frontiers in Endocrinology, 2023 - frontiersin.org
… , renal growth was significantly attenuated, and molecular markers of renal growth were …
diabetes-induced rise in renal expression of markers of kidney growth by reducing the cyclin-…

Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets

J Barrera‐Chimal, F Jaisser - Diabetes, Obesity and …, 2020 - Wiley Online Library
… The involvement of several molecular mechanisms in DKD pathogenesis, together with
the genetic and epigenetic variability of this condition, makes it difficult to target this …

Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms

E Ahmadian, SM Hosseiniyan Khatibi… - Reviews in medical …, 2021 - Wiley Online Library
… AKI, proposing the probability of extensive subclinical renal damage. Different assumptions
have been proposed regarding the molecular mechanism of viral-induced rhabdomyolysis. (1…

A molecular mechanism explaining albuminuria in kidney disease

L Butt, D Unnersjö-Jess, M Höhne, A Edwards… - Nature …, 2020 - nature.com
… Although decades of research on the glomerular filtration barrier have markedly expanded
knowledge about its properties, the exact molecular mechanism by which the filter allows …

New insights into the role and mechanism of partial epithelial-mesenchymal transition in kidney fibrosis

L Sheng, S Zhuang - Frontiers in physiology, 2020 - frontiersin.org
… progression of renal fibrosis. Moreover, the cellular and molecular mechanisms mediating
… A better understanding of the complex mechanisms and related cellular mediators of kidney

The glomerular filtration barrier: a structural target for novel kidney therapies

IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
… The risk of developing other kidney diseases including hypertensive nephrosclerosis,
lupus nephritis, pre-eclampsia, kidney transplant nephropathy and sickle cell nephropathy is …

The fibrogenic niche in kidney fibrosis: components and mechanisms

L Li, H Fu, Y Liu - Nature Reviews Nephrology, 2022 - nature.com
… approach to identifying the mechanisms of kidney fibrosis. In this article, we review the
composition, function and mechanisms of action of the fibrogenic niche in kidney fibrosis. We also …