[HTML][HTML] A single-cell transcriptomic landscape of the lungs of patients with COVID-19

S Wang, X Yao, S Ma, Y Ping, Y Fan, S Sun, Z He… - Nature cell …, 2021 - nature.com
… atlas of the lungs from the patients with COVID-19. In a series of verification experiments,
our data link COVID-19-associated changes in lung phenotypes and functions with cell type-…

Inside the lungs of COVID-19 disease

D Aguiar, JA Lobrinus, M Schibler, T Fracasso… - International journal of …, 2020 - Springer
… a COVID-19 fatality occurring in a young woman, in the community. Diagnosis was made at
necropsy and lung … pattern, mostly affecting the central part of the lungs. This death related to …

[HTML][HTML] The spatial landscape of lung pathology during COVID-19 progression

AF Rendeiro, H Ravichandran, Y Bram, V Chandar… - Nature, 2021 - nature.com
… structural cell types during SARS-CoV-2 infection in the lung, we performed imaging mass
cytometry (IMC) in post-mortem lung tissue from patients with COVID-19 or with other lung

A molecular single-cell lung atlas of lethal COVID-19

JC Melms, J Biermann, H Huang, Y Wang, A Nair… - Nature, 2021 - nature.com
… We found significant differences in cell fractions between COVID-19 and control lungs both
globally (Fig. 1d) and within the immune and non-immune compartments (Extended Data Fig. …

Two distinct immunopathological profiles in autopsy lungs of COVID-19

R Nienhold, Y Ciani, VH Koelzer, A Tzankov… - Nature …, 2020 - nature.com
… signature (CD38, GZMA, GZMB, CCR5) consisting of CD8 + T cell markers that are associated
with severe COVID-19 infection 15, 16 , and we found that it was inversely correlated to …

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

R Alon, M Sportiello, S Kozlovski, A Kumar… - Nature Reviews …, 2021 - nature.com
cell migration and function in distinct airway and lung … in patients with severe coronavirus
disease 2019 (COVID-19). We … cells, vascular cells, stromal cells, resident immune cells and …

The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing

M Liao, Y Liu, J Yuan, Y Wen, G Xu, J Zhao, L Chen… - MedRxiv, 2020 - medrxiv.org
… to a better control of COVID-19. This study first reported the cellular atlas of lung
bronchoalveolar immune microenvironment in COVID-19 patients at the single-cell resolution, and …

Immune signatures underlying post-acute COVID-19 lung sequelae

IS Cheon, C Li, YM Son, NP Goplen, Y Wu… - Science …, 2021 - science.org
… functional and pathological parameters to identify the potential involvement of different
immune cells in post–COVID-19 lung sequelae. Last, we performed scRNA-seq to identify …

Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment

VMM Giménez, F Inserra, CD Tajer, J Mariani, L Ferder… - Life sciences, 2020 - Elsevier
… between COVID-19 and renin-angiotensin system (RAS). It has been shown that COVID-19
2 receptors (ACE2r) to invade human lung epithelial cells and to initiate the infection. At the …

Pulmonary alveolar regeneration in adult COVID-19 patients

J Chen, H Wu, Y Yu, N Tang - Cell research, 2020 - nature.com
… Our results demonstrate that alveolar regeneration in COVID-19 lungs was initiated by (at
the latest) the 38th day after the onset of initial symptoms. These observations indicate that it …