Dysregulation of lung myeloid cells in COVID-19

B Salomé, A Magen - Nature Reviews Immunology, 2020 - nature.com
… of COVID-19, but the functional state of T cells in these patients is not known. Based on the
retrospective study of 522 patients with COVID-19 … 14 patients with COVID-19 and 3 controls. …

Myeloid dysregulation and therapeutic intervention in COVID-19

R Gu, T Mao, Q Lu, TT Su, J Wang - Seminars in immunology, 2021 - Elsevier
myeloid cell dysregulation, leading to immunopathology and severe disease, and discuss
potential therapeutic strategies targeting myeloid cells as a new paradigm for COVID-19

[HTML][HTML] Severe COVID-19 is marked by a dysregulated myeloid cell compartment

J Schulte-Schrepping, N Reusch, D Paclik, K Baßler… - Cell, 2020 - cell.com
… signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence
of … profound alterations in the myeloid cell compartment associated with severe COVID-19. …

[HTML][HTML] Myeloid-derived suppressor cells as a potential biomarker and therapeutic target in COVID-19

M Rowlands, F Segal, D Hartl - Frontiers in immunology, 2021 - frontiersin.org
… cell compartment, with increased myeloid-… and myeloid cell dysregulation in COVID-19
infection and discuss the potential of MDSCs as biomarkers and therapeutic targets in COVID-19

Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion

A Mazzoni, L Salvati, L Maggi, F Annunziato… - Seminars in …, 2021 - Elsevier
… The six hallmarks are dysregulated type I IFN activity, hyperinflammation, … , dysregulated
myeloid response, and heterogeneous adaptive immunity to SARS-CoV-2. Dysregulation and …

[HTML][HTML] Myeloid cells in COVID-19 microenvironment

G Qin, S Liu, L Yang, W Yu, Y Zhang - Signal Transduction and …, 2021 - nature.com
… another myeloid cell subset is significant for the poor prognosis of severe COVID-19 patients…
trajectory of myeloid cells and critical transcription factors in COVID-19 patients provides a …

[HTML][HTML] Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19

S Mairpady Shambat, A Gomez-Mejia… - PLoS …, 2022 - journals.plos.org
… ill COVID-19 patients. Our data provides insights into the transient functional dysregulation
of myeloid immune cells against subsequent bacterial infections in COVID-19 patients and …

[HTML][HTML] Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

A Silvin, N Chapuis, G Dunsmore, AG Goubet… - Cell, 2020 - cell.com
myeloid cells are known to be dysregulated in coronavirus … cell RNA sequencing of COVID-19
patient peripheral blood cells … develop a severe form of COVID-19, suggesting a predictive …

[HTML][HTML] Dysregulated hematopoiesis in bone marrow marks severe COVID-19

X Wang, Y Wen, X Xie, Y Liu, X Tan, Q Cai, Y Zhang… - Cell discovery, 2021 - nature.com
… and myeloid compartments in COVID-19 patients. In this study, we used single-cell RNA
sequencing to assess bone marrow mononuclear cells from COVID-19 … of immature myeloid

COVID-19 disease and immune dysregulation

E Davitt, C Davitt, MB Mazer, SS Areti… - Best Practice & …, 2022 - Elsevier
… levels of STAT3 phosphorylation in myeloid and lymphocytic cells [… was accompanied by
decreased myeloid cell activation in … pathway for the dysregulation observed in COVID-19 [18]. …