The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
… inflammasome in COVID-19, this review describes the possible pathways of … COVID-19
and promising treatments based on the inhibition of the NLRP3 inflammasome in COVID-19

[HTML][HTML] COVID-19 and oxidative stress

BV Chernyak, EN Popova, AS Prikhodko… - Biochemistry …, 2020 - Springer
… Both endothelial pro-inflammatory activation as well as RAGE expression are driven by the
transcription factor NF-κB implicating that this signaling pathway is targeted by mtROS. This …

Contribution of STAT3 to the pathogenesis of COVID-19

A Jafarzadeh, M Nemati, S Jafarzadeh - Microbial pathogenesis, 2021 - Elsevier
… IL-6 operates via two major signaling pathways named cis or trans. In cis pathway, IL-6
initially … This signaling pathway exerts pleiotropic impacts of IL-6 on the innate- (macrophages, …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
… which target the COVID-19 induced cytokine storm. As this is not exclusive to COVID-19, we
… Acting directly on the IL-6 R, TCZ can inhibit both classical and trans-signaling pathways

[HTML][HTML] … immunity trained by coronavirus infections, DAMP stimulations and regulated by anti-oxidant NRF2 may contribute to inflammations, myelopoiesis, COVID-19 …

Y Shao, J Saredy, K Xu, Y Sun, F Saaoud… - Frontiers in …, 2021 - frontiersin.org
… coli), which mediated by the EC-intrinsic TLR4/Myd88 signaling pathway (16). This … death
pathways, including apoptosis and necroptosis might lead to the lung damage in the COVID-19

Role of arachidonic cascade in COVID-19 infection: A review

MAR Ripon, DR Bhowmik, MT Amin… - Prostaglandins & Other …, 2021 - Elsevier
… In contrast, the clinical study suggested that COVID-19 infected patients admitted in the … for
published materials on COVID 19 and the arachidonic acid (AA) pathway. This study gathered …

… and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): in silico and …

R Yang, H Liu, C Bai, Y Wang, X Zhang, R Guo… - Pharmacological …, 2020 - Elsevier
… mapped the drug-disease network of Qingfei Paidu Decoction and COVID-19 on the toll-like
signaling pathway. Results were visualized with wikipathway plugin of Cytoscape software. …

[HTML][HTML] A hypothesized role for dysregulated bradykinin signaling in COVID19 respiratory complications

JA Roche, R Roche - The FASEB Journal, 2020 - ncbi.nlm.nih.gov
… that dysregulated BK signaling is involved in COVID19 respiratory complications for the …
on BK signaling pathways, might also be able to reduce the respiratory distress in COVID19. …

COVID-19: inflammatory profile

Y Wang, S Perlman - Annual review of medicine, 2022 - annualreviews.org
signaling) in severe COVID-19 patients (18). Patients with inherited deficiencies in proteins
involved in the IFN-I production or signaling pathways, … -κB pathway in severe COVID-19 may …

[HTML][HTML] The many faces of JAKs and STATs within the COVID-19 storm

AH Grant, A Estrada III, YM Ayala-Marin… - Frontiers in …, 2021 - frontiersin.org
… (JAKs) and Signal Transducers and Activators of … Coronavirus Disease 2019 (COVID-19).
In this report, cytokines found in the storm are discussed in relation to the JAK-STAT pathway