… , disease. Beginning with events in the very deep past, where most genes and pathways
involved in human disease originate, we explain how ancient biological systems, recent genetic …

… diseases, benefits understudied diseases, and improves risk prediction while also enabling
the nomination of disease genes and drug candidates by incorporating gene … diseases and …

… The second enabler of inclusive, systematic analysis of genotype–phenotype relationships
has been access to whole-genome sequence data. The scale of genetic analysis based on …

… by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a
… human brain in health and disease. Building on large-scale genetic studies that discovered …

… Therefore, differences in methodologies and/or analyses (for example in the DNA extraction
method, the region of the genes sequenced and the bioinformatics approaches used) may …

… of AD (7, 33), we performed candidate gene analyses for the astrocyte subclusters and
found that genes related to cholesterol homeostasis, K + homeostasis, neurotransmitter …

… genetic basis of Parkinson's disease has advanced considerably, much remains to be done.
Further disease-related common genetic … little of the genetics of Parkinson's disease in other …

… , more-severe cases of disease, it is important that our results also reveal genes that may
act to drive inflammatory organ injury. TYK2 is one of four gene targets for JAK inhibitors such …

… disease impacts of testosterone and highlight the importance of sex-specific genetic analyses…
specific analyses, both in the discovery of genetic variants for sex hormone traits and in the …

… and preexisting health conditions, we did not find evidence that these two primary genetic
… This analysis identified two loci with robust associations (Fig. 3a and Supplementary Table 2…