… of apelin and elabela peptide ligands in cardiovascular diseases, including heart failure and
… This article aims to review the roles of apelin and elabela peptide ligands in cardiovascular …

… of heart failure, monitoring of treatment and accurate assessment of prognosis [5]. A promising
contemporary marker is the apelin … Apelin is a newly discovered peptide hormone and …

… of apelin/ELA-APJ signal activation as therapeutic strategy in hypertension, MI, and heart
failure. … associated with the development of apelin and ELA peptide analogues, providing an …

… cleavage of (pyr)-apelin-13 and apelin-17 along with total apelin, because it was not a
purpose of the study to elucidate binding of pyr-apelin 13 and apelin 17 to their targets, such as …

… As later explained in the Vasculature and Heart subsections, a decreased degradation of
apelin peptides would have positive effects in heart failure due to the vasodilatory (reduced …

… From a 77-amino acid protein, the angiotensin-converting enzyme splits apelin-13, which
is the most forceful peptide and the shortest of all the fragments derived from pre-pro-…

… peptide, which plays a pivotal role in adverse cardiac remodeling and the occurrence of heart
failure (… The purpose of the study was to investigate whether serum levels of apelin predict …

… New heart failure therapies that safely augment cardiac contractility and output are needed.
Previous apelin peptide studies have highlighted the potential for APJ (apelin receptor) …

… Baseline-adjusted mean levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) in
Part C for patients with heart failure with reduced ejection fraction (HFrEF). Dotted line …

… Apelin is a multifunctional peptide that plays a pivotal role in … with HF might be mediated by
apelin and that its levels seem to … levels of apelin and N-terminal brain natriuretic pro-peptide (…