SARS-CoV-2 productively infects human brain microvascular endothelial cells

RC Yang, K Huang, HP Zhang, L Li, YF Zhang… - Journal of …, 2022 - Springer
… of the vascular endothelium in brain. Moreover, we demonstrated that SARS-CoV-2 infection
could … Our findings demonstrated that SARS-CoV-2 infection can cause BBB dysfunction, …

[PDF][PDF] SARS-CoV-2 infection and persistence throughout the human body and brain

D Chertow, S Stein, S Ramelli, A Grazioli, JY Chung… - 2021 - academia.edu
… -2 cellular 260 tropism, quantification, and persistence across the body and brain, in a diverse
… We show SARS-CoV-2 disseminates across the human body and brain early in infection …

[HTML][HTML] SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids

L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul… - Cell stem cell, 2020 - cell.com
… Here, we use human-pluripotent-stem-cell-derived brain organoids to examine SARS-CoV-2 …
We challenge organoids with SARS-CoV-2 spike pseudovirus and live virus to demonstrate …

[HTML][HTML] What SARS-CoV-2 does to our brains

T Aschman, R Mothes, FL Heppner, H Radbruch - Immunity, 2022 - cell.com
… observed after SARS-CoV-2 infection could be (1) directly caused by the virus infecting brain
cells, … As indisputable evidence of intact and replicating SARS-CoV-2 particles in the central …

SARS-CoV-2 infectivity and neurological targets in the brain

WJ Lukiw, A Pogue, JM Hill - Cellular and molecular neurobiology, 2022 - Springer
… of the mechanism and pathways of SARS-CoV-2 infection and … SARS-CoV-2 attack in this
communication we analyzed ACE2 expression in 85 human tissues including 21 different brain

SARS-CoV-2 infects human neural progenitor cells and brain organoids

BZ Zhang, H Chu, S Han, H Shuai, J Deng, Y Hu… - Cell research, 2020 - nature.com
… whether SARS-CoV-2 could infect 3D human brain organoids. We generated iPSC-derived
human brain organoids using previously described protocols. The 35-day-old brain

Neurological complications and infection mechanism of SARS-COV-2

D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
… -2 and discuss the potential mechanisms through which SARS-CoV-2 invades the brain
based on the current evidence. Finally, we summarize the experimental models were used to …

Possible routes of SARSCoV‐2 invasion in brain: in context of neurological symptoms in COVID‐19 patients

A Kumar, V Pareek, P Prasoon, MA Faiq… - Journal of …, 2020 - Wiley Online Library
… —crossing the blood–brain barrier, routes have been … may be multiple routes of SARS-CoV-2
entry into the brain, or … the possible routes of SARS-CoV-2 brain entry based on the …

Neuroinvasion of SARS-CoV-2 in human and mouse brain

E Song, C Zhang, B Israelow, A Lu-Culligan… - Journal of Experimental …, 2021 - rupress.org
… mice, and infections of human brain organoids: that SARS-CoV-2 … , and the disruption of brain
vasculature can make vulnerable … of human brain organoids, beyond modeling fetal brains, …

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids

n Samudyata, AO Oliveira, S Malwade… - Molecular …, 2022 - nature.com
… To a large extent, SARS-CoV-2 exposed microglia adopt a transcriptomic profile … risk
after a SARS-CoV-2 infection. Our results reveal that brain organoids infected with SARS-CoV-2 …