[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
… need to better understand the molecular mechanisms driving diabetic kidney disease to help
identify … of molecular mechanisms that drive DKD pathogenesis is presented as a basis for …

A molecular mechanism explaining albuminuria in kidney disease

L Butt, D Unnersjö-Jess, M Höhne, A Edwards… - Nature …, 2020 - nature.com
… Although decades of research on the glomerular filtration barrier have markedly expanded
knowledge about its properties, the exact molecular mechanism by which the filter allows …

Oxidative stress in human pathology and aging: molecular mechanisms and perspectives

YA Hajam, R Rani, SY Ganie, TA Sheikh, D Javaid… - Cells, 2022 - mdpi.com
… Studies have shown that specific genes called oncogenes are able to induce cellular
transformation, thereby providing the first insights into the molecular basis of cancer. …

Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms

E Ahmadian, SM Hosseiniyan Khatibi… - Reviews in medical …, 2021 - Wiley Online Library
… AKI, proposing the probability of extensive subclinical renal damage. Different assumptions
have been proposed regarding the molecular mechanism of viral-induced rhabdomyolysis. (1…

[HTML][HTML] Duplex kidney formation: developmental mechanisms and genetic predisposition

VM Kozlov, A Schedl - F1000Research, 2020 - ncbi.nlm.nih.gov
molecular programs responsible for ureter induction, review the genes that have been identified
as risk factors in duplex kidney formation and discuss molecularKidney development in …

The glomerular filtration barrier: a structural target for novel kidney therapies

IS Daehn, JS Duffield - Nature Reviews Drug Discovery, 2021 - nature.com
… in human kidney cells, including podocytes. The G1 and G2 variants also traffic selectively
to membranes in the endoplasmic reticulum and mitochondria in podocytes, and may directly …

Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets

J Barrera‐Chimal, F Jaisser - Diabetes, Obesity and …, 2020 - Wiley Online Library
… The involvement of several molecular mechanisms in DKD pathogenesis, together with
the genetic and epigenetic variability of this condition, makes it difficult to target this …

Recent advances on the mechanisms of kidney stone formation

Z Wang, Y Zhang, J Zhang… - … journal of molecular …, 2021 - spandidos-publications.com
… The most common types of human kidney stones are CaOx and calcium phosphate (CaP),
either alone or combined, which are calcareous and radio-opaque stones (9,11). …

New insights into the role and mechanism of partial epithelial-mesenchymal transition in kidney fibrosis

L Sheng, S Zhuang - Frontiers in physiology, 2020 - frontiersin.org
… progression of renal fibrosis. Moreover, the cellular and molecular mechanisms mediating
… A better understanding of the complex mechanisms and related cellular mediators of kidney

The mechanism of drug nephrotoxicity and the methods for preventing kidney damage

E Kwiatkowska, L Domański, V Dziedziejko… - … Journal of Molecular …, 2021 - mdpi.com
… ); (3) interstitial nephritis induced by drugs and their metabolites (a dose-independent
mechanism). In this article, the mechanisms of the individual types of injury will be described. …