… cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to counter cytokine storm

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
Cytokine storm is an extremely deadly immune disorder characterized by abrupt … over 150
chemical mediators and inflammatory cytokines by non-immune as well as immune cells [36,37…

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
… Here, we discuss recent progress in innate immunity and inflammatory cell death, providing
insights into the cellular and molecular mechanisms of CSs and therapeutics that might quell …

The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… innate immune cells, resulting in cytokine storms. Collectively, the impaired acquired immune
… uncontrolled inflammatory innate responses to SARS-CoV-2 may cause cytokine storms. …

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
… with profiles of cytokines released during cytokine storm varying … mechanisms underlying
cytokine storm induction and … If cytokine storm occurs, the body’s immune system will …

Controlling cytokine storm is vital in COVID-19

L Tang, Z Yin, Y Hu, H Mei - Frontiers in immunology, 2020 - frontiersin.org
cytokine storms induced by COVID-19, as well as potential intervention strategies to control
cytokine storms. … , among which the pro-inflammatory cytokines could promote more immune

[HTML][HTML] Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections

KE Remy, M Mazer, DA Striker, AH Ellebedy… - JCI insight, 2020 - ncbi.nlm.nih.gov
… ) and adaptive cellular immunity (blood … cytokine storm versus an immunosuppressive
immunological endotype, and determine whether there are changes in immune function during …

[HTML][HTML] Immune system response during viral Infections: Immunomodulators, cytokine storm (CS) and Immunotherapeutics in COVID-19

FH Pottoo, T Abu-Izneid, AM Ibrahim, MN Javed… - Saudi pharmaceutical …, 2021 - Elsevier
… of “immunocytokines” resulting in cytokine storm (CS); … cytokine storm are now being
considered as a new paradigm shift in the clinical management of SARS-CoV-2. Tocilizumab (IL-6

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
… epithelial cells and immune cells in COVID-19, which has linked the cytokine storm (CS) …
the overproduction of inflammatory cytokines and excessive activation of immune cells lead to …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
… These processes can contribute to cytokine storm, tissue … immune activation and the
contribution of this innate immune … for innate immunity driving cytokine storm and organ damage …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… The human innate and adaptive immune systems consist of effector cells producing cytokines
(interleukins, interferons, chemokines, and numerous other mediators). Usually, a fragile …