… Here, we discuss recent progress in innate immunity and inflammatory cell death, providing insights into the cellular and molecular mechanisms of CSs and therapeutics that might quell …
B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
… innate immune cells, resulting in cytokinestorms. Collectively, the impaired acquired immune … uncontrolled inflammatory innate responses to SARS-CoV-2 may cause cytokinestorms. …
XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
… with profiles of cytokines released during cytokinestorm varying … mechanisms underlying cytokinestorm induction and … If cytokinestorm occurs, the body’s immune system will …
L Tang, Z Yin, Y Hu, H Mei - Frontiers in immunology, 2020 - frontiersin.org
… cytokinestorms induced by COVID-19, as well as potential intervention strategies to control cytokinestorms. … , among which the pro-inflammatory cytokines could promote more immune …
KE Remy, M Mazer, DA Striker, AH Ellebedy… - JCI insight, 2020 - ncbi.nlm.nih.gov
… ) and adaptive cellular immunity (blood … cytokinestorm versus an immunosuppressive immunological endotype, and determine whether there are changes in immunefunction during …
… of “immunocytokines” resulting in cytokinestorm (CS); … cytokinestorm are now being considered as a new paradigm shift in the clinical management of SARS-CoV-2. Tocilizumab (IL-6 …
L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
… epithelial cells and immune cells in COVID-19, which has linked the cytokinestorm (CS) … the overproduction of inflammatory cytokines and excessive activation of immune cells lead to …
… These processes can contribute to cytokinestorm, tissue … immune activation and the contribution of this innate immune … for innate immunity driving cytokinestorm and organ damage …
D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… The human innate and adaptive immune systems consist of effector cells producing cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a fragile …