Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
… Understanding the pathogenesis of cytokine storm will help … In this article, we present an
overview of the cytokine storm and … paper provides critical insights on cytokine storm from both a …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (… mechanisms is …

… cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to counter cytokine storm

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
… of cytokine storm; hence, various mechanisms, immunological pathways, and functions of
cytokines and … A thorough understanding of cytokines’ molecular pathways and their activation …

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
… The inadequate immune response to the virus has been proposed as a possible
mechanism in the development of cytokine storms during SARS-CoV-2 infection [36,37]. As …

Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
… If the inflammatory reaction is very pronounced, an ultimately uncontrolled release of
proinflammatory cytokines leads to cytokine storm with the known potentially lethal courses [168]. …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
… Herein, we discuss the latest developments in the immunopathological characteristics of
COVID-19 and focus on CS including the current research status of the different cytokines

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”

GH Meftahi, Z Jangravi, H Sahraei, Z Bahari - Inflammation Research, 2020 - Springer
… critical adults leads to a cytokine storm, which is characterized by severe systemic elevation
of several pro-inflammatory cytokines. Then, a cytokine storm can induce edematous, ARDS, …

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
cytokine storm induction and progression, with profiles of cytokines released during cytokine
storm … This review focuses on pathophysiological mechanisms underlying cytokine storm

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
… Since the first textbook devoted to cytokine storm syndromes (CSSs) was published in 2019,
… organ-threatening systemic inflammation and immunopathology regardless of the context in …

On the alert for cytokine storm: immunopathology in COVID‐19

LA Henderson, SW Canna, GS Schulert… - Arthritis & …, 2020 - Wiley Online Library
… and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm
and early, targeted antiinflammatory therapy may prevent immunopathology and could help …