Cytokine storm is the cryptic killer behind coronavirus disease-2019 infections, review of the current evidence to identify therapeutic options

D Alrahmany, IM Ghazi - Reviews and Research in Medical …, 2021 - journals.lww.com
… The objective of this article is to review the involvement of inflammatory mediators in
cytokine storm syndrome (CSS) and highlight the possibility of … The cytokine storm syndrome …

[HTML][HTML] COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
… of cytokines has been identified as one of the key factors behind poorer outcomes in COVID-19.
This “cytokine storm” … available about the role of the cytokine storm in COVID-19 disease …

Cytokine storm and probable role of immunoregulatory drugs in COVID-19: a comprehensive review

A Sadeghzadeh-Bazargan, E Behrangi… - Iranian Journal of …, 2020 - iranjd.ir
… Since it is postulated that the cytokine storm may be … and related articles about the
immunopathology of COVID-19, … drugs that can affect these mechanisms. We used the Medline, …

[PDF][PDF] Mechanism of Cytokine Storm in COVID-19: How can probiotics combat it

MS Reddy - JAAPI, 2021 - aapiusa.org
… definition, cytokine storm is an activation cascade of auto-amplifying cytokine production due
to … Before we proceed with the pathophysiology of COVID-19 induced cytokine storm, it is …

Cascade of immune mechanism and consequences of inflammatory disorders

KB Megha, X Joseph, V Akhil, PV Mohanan - Phytomedicine, 2021 - Elsevier
… -associated autoimmunity, immunopathology and allergic … for cytokine storm has become
an essential part of rescuing severe patients. The specific phenomenon namely the cytokine

[HTML][HTML] Radiotherapy and cytokine storm: risk and mechanism

C Zhang, Z Liang, S Ma, X Liu - Frontiers in Oncology, 2021 - frontiersin.org
… responses induced by radiation, especially the cytokine storm and the underlying mechanisms
such as DAMPs release, pro-inflammatory cytokine secretion and cGAS-STING pathway …

[HTML][HTML] Therapeutic role of tocilizumab in SARS-CoV-2-induced cytokine storm: rationale and current evidence

C Pelaia, C Calabrese, E Garofalo, A Bruni… - International Journal of …, 2021 - mdpi.com
… Based on the above considerations, the present review article aims to discuss the
immunopathology of the cytokine storm caused by SARS-CoV-2 infection, as well as to focus on the …

[HTML][HTML] Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?

LYR Wong, S Perlman - Nature Reviews Immunology, 2022 - nature.com
… of the mechanisms involved in each of these scenarios. … scientists have described the
immunopathological nature of immune … We also describe and discuss the immunopathological

Coronavirus disease-2019: A review on the disease exacerbation via cytokine storm and concurrent management

H Sunkara, SMR Dewan - International immunopharmacology, 2021 - Elsevier
… In this review, we focused on the current treatment approaches targeting the crucial
causative factors for the disease burden through cytokine storm or cytokine release syndrome. …

[HTML][HTML] The immunopathological and histological landscape of COVID-19-mediated lung injury

G Zarrilli, V Angerilli, G Businello, M Sbaraglia… - International Journal of …, 2021 - mdpi.com
immunopathological mechanisms of … The immunopathological scenario of COVID-19 is
poorly characterized as well. The so-called cytokine storm has been proposed as a mechanism