Blood-stage malaria vaccine candidate RH5. 1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre …

SE Silk, WF Kalinga, J Salkeld, IM Mtaka… - The Lancet Infectious …, 2024 - thelancet.com
… Matrix-M vaccine candidate shows an acceptable safety and … children residing in a
malaria-endemic area, with all children in … vaccine candidate against clinical malaria in young …

[HTML][HTML] A brief history of selected malaria vaccine and medical interventions pursued by the Swiss Tropical and Public Health Institute and partners, 1943-2021

L Meier, G Casagrande, S Abdulla, H Masanja - Acta Tropica, 2022 - Elsevier
… (from Patarroyo's team) tests of SPf66 to be conducted in other … The Idete trial including 586
children aged 1-5 years was the … “It wasn't about travelling to Tanzania to collect a few blood …

Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

AA El-Moamly, MA El-Sweify - Tropical Medicine and Health, 2023 - Springer
… we expect many more African children to be protected from malaria and grow into healthy
adults.” … In 1988, asexual stage vaccine (SPf66 candidate), emerged in Colombia and had an …

Malaria Vaccines

MB Laurens, CV Plowe - Infectious Diseases, 2023 - Springer
… risk of anemia in vaccinated malaria-exposed children in an … One of the earliest was SPf66,
a synthetic vaccine consisting of … in Tanzanian adults [177]. A study in Kenyan infants and …

Modelling the within-host dynamics of Plasmodium vivax hypnozoite activation: an analysis of the SPf66 vaccine trial

S Mehra, F Nosten, C Luxemburger, NJ White… - medRxiv, 2024 - medrxiv.org
… In the SPf66 vaccine trial, both vivax and falciparum malaria were frequent in children,
and … episodes per child for our implementation, which is the maximum observed in the …

[HTML][HTML] Future use-cases of vaccines in malaria control and elimination

MA Penny, F Camponovo, N Chitnis, TA Smith… - Parasite epidemiology …, 2020 - Elsevier
… one, SPf66, undertook a phase 3 trial in infants (Genton and Reed, 2007; Acosta et al., 1999a).
The latter trial of SPf66 … from Tanzanian and Mozambican children in the RTS,S malaria

Progress in the development of subunit vaccines against malaria

M Skwarczynski, S Chandrudu, B Rigau-Planella… - Vaccines, 2020 - mdpi.com
… The Spf66 vaccine construct was able to induce higher antibody titers and … a malaria
vaccine, ten Tanzanian adults and 40 children aged between 5 and 9 years old living in a malaria-…

Plasmodium falciparum Malaria Vaccines and Vaccine Adjuvants

SR Bonam, L Rénia, G Tadepalli, J Bayry, HMS Kumar - Vaccines, 2021 - mdpi.com
… on the brain vasculature of 31 children who died from human cerebral malaria. A substantial
number of … The vaccination of multistage antigen SpF66 combined with alum resulted in the …

Plasmodium falciparum merozoite surface protein 1 as asexual blood stage malaria vaccine candidate

R Thomson-Luque, TC Stabler, K Fürle… - … Review of Vaccines, 2024 - Taylor & Francis
… disease in African children Citation13 has recently been … The SPf66 vaccine, which includes
amino acid sequences from a conserved region of MSP1-83, was the first malaria vaccine to …

[HTML][HTML] Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with sera from Plasmodium falciparum endemic areas of Africa

S Balam, K Miura, I Ayadi, D Konaté, NC Incandela… - bioRxiv, 2024 - ncbi.nlm.nih.gov
… (≥ 17 years) than young children (≤ 5 years) in both Mali and Tanzania, with a higher … of
the community from malaria-endemic countries of Mali, Tanzania, Burkina Faso and Nigeria, as …