… treatments due to their diversity has significantly improved. This study summarized the current
therapeutic approaches (Figure 1) for COVID-19 … , inhibition of the JAK/STAT pathway is a …

… that several immune pathways and pro-… inhibitors, RNA synthesis inhibitors, convalescent
plasma, and traditional herbal medicines have also been utilized in the treatment of COVID-19 […

… By inhibiting the Janus kinase (JAK)-signal transducer and activator of transcription (JAK-STAT)
pathway, JAK inhibitors are hypothesized to play a role in the management of CRS in …

… coronavirus 2 (SARS-CoV-2) and designated as COVID-19. Here, we have collected all data
related to the potential inhibitory … by inhibition of MAPK pathways, leading to inhibition of the …

… However, blockage of JAK-STAT pathway leads to inhibition of IFN production which may
cause impairment of anti-viral immunity [25]. Currently, 20 clinical trials are ongoing for …

… Likewise, thrombin increased the release of macrophage migration inhibitory factor in … of
activated B cells) pathway. Disrupting this pathway was shown to inhibit the ability of thrombin to …

… The COVID-19 may present with mild and moderate disease (… and treatment for COVID-19,
the first therapeutic strategy for … –7)/Mas receptor pathway was inhibited and an imbalance in …

… pathways in … pathways in SARS-CoV-2 infection. Whether or not this speculation is confirmed,
the key conclusion from the INBUILD study was that nintedanib therapy appears to inhibit …

… ZIKV is thought to inhibit the Akt–mTOR pathway promoting … Treatment with metformin was
found to inhibit ZIKV in vitro. … of mTOR inhibitors and modulators in the treatment of COVID-19. …

… Patients with severe COVID-19 experience elevated plasma levels of pro-inflammatory …
)1/JAK2, inhibition of these pathways with ruxolitinib has the potential to mitigate the COVID-19–…