Reactivation of VX-inhibited human acetylcholinesterase by deprotonated pralidoxime. A complementary quantum mechanical study

JAV da Silva, AF Pereira, SR LaPlante, K Kuca… - Biomolecules, 2020 - mdpi.com
… This corroborates our hypothesis that the reactivation mechanism might be triggered by
the … to a better understanding of the mechanism of reactivation of HssAChE by pyridinium-…

A systematic analysis of signaling reactivation and drug resistance

BN Kholodenko, N Rauch, W Kolch, OS Rukhlenko - Cell reports, 2021 - cell.com
mechanisms that lead to complete pathway reactivation or overshoot, we identify network
topologies that can mediate full pathway reactivation … required for full reactivation or increase of …

Role of prelimbic cortex PKC and PKMζ in fear memory reconsolidation and persistence following reactivation

TR da Silva, AM Raymundi, LJ Bertoglio… - Scientific Reports, 2020 - nature.com
… Next, by omitting memory reactivation, we assessed the requirement of this process to
induce memory persistence mechanisms. Finally, we addressed whether PKC and/or PKMζ is …

Systems pharmacology reveals the multi-level synergetic mechanism of action of Ginkgo biloba L. leaves for cardiomyopathy treatment

Y Li, C Xu, H Wang, X Liu, L Jiang, S Liang… - Journal of …, 2021 - Elsevier
… However, because of the widely known holistic therapeutic philosophy via multi-target and
multi-pathway effect for most TCMs, to explore its underlying molecular mechanisms of action (…

Therapeutic potential of p53 reactivation in prostate cancer: Strategies and opportunities

S Kumari, V Sharma, R Tiwari, JP Maurya… - European Journal of …, 2022 - Elsevier
… Despite significant progress in the development of p53-reactivating compounds, there
remains so much to learn about the mechanism of action of these compounds. It would be …

Reactivation characteristics and hydrological inducing factors of a massive ancient landslide in the three Gorges Reservoir, China

C Zhang, Y Yin, H Yan, H Li, Z Dai, N Zhang - Engineering Geology, 2021 - Elsevier
… Under the combined action of an increase in the hydraulic gradient … Our combined monitoring
data and field investigation show … the combined action of rainfall and changes in the RWLs. …

Investigation of mining-induced fault reactivation associated with sublevel caving in metal mines

K Xia, C Chen, T Wang, K Yang, C Zhang - Rock Mechanics and Rock …, 2022 - Springer
… joint surface under the action of the abutment pressure. In this study, the behavior of the
columnar rock masses at the side of the mined-out area under the combined action of horizontal …

Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation

M Bauer, E Vidal, E Zorita, N Üresin, SF Pinter… - Nature …, 2021 - nature.com
… the chromosome through the combined action of multiple … transcriptional silencing, the
mechanisms of transition to the … is reversed during the reactivation of the X chromosome has …

Model-based aversive learning in humans is supported by preferential task state reactivation

T Wise, Y Liu, F Chowdhury, RJ Dolan - Science Advances, 2021 - science.org
combined with magnetoencephalography, we show prospective and retrospective reactivation
… Specifically, when individuals plan in an aversive context, we find preferential reactivation

Multiple activation mechanisms of CaO-based sorbents promoted by pre-sintering-hydration

M Li, C Shen, J Ji, L Li, Y Wu - Journal of Environmental Chemical …, 2022 - Elsevier
… to the combined action of multiple active mechanisms … It should be noted that, most reactivated
CaO sorbents after … the cyclic stability of such reactivated sorbents simultaneously [37]. …