An overview of similarities and differences in metabolic actions and effects of central nervous system between glucagon-like peptide-1 receptor agonists (GLP-1RAs) …

S Wen, T Nguyen, M Gong, X Yuan… - Diabetes, Metabolic …, 2021 - Taylor & Francis
Abstract GLP-1 receptor agonists (GLP-1RAs) and SGLT-2 inhibitors (SGLT-2is) are novel
antidiabetic medications associated with considerable cardiovascular benefits therapying …

The relationship between the blood-brain-barrier and the central effects of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors

M Dong, S Wen, L Zhou - Diabetes, Metabolic Syndrome and …, 2022 - Taylor & Francis
Diabetes and obesity are growing problems worldwide and are associated with a range of
acute and chronic complications, including acute myocardial infarction (AMI) and stroke …

The neuronal and non-neuronal pathways of sodium-glucose cotransporter-2 inhibitor on body weight-loss and insulin resistance

M Dong, H Chen, S Wen, Y Yuan, L Yang… - Diabetes, Metabolic …, 2023 - Taylor & Francis
With the emergence of sodium-glucose cotransporter 2 inhibitors (SGLT2i), the treatment of
type 2 diabetes mellitus (T2DM) has achieved a new milestone, of which the insulin …

Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors, anti-diabetic drugs in heart failure and cognitive impairment: potential …

MA Riemma, E Mele, M Donniacuo… - Frontiers in …, 2024 - frontiersin.org
Heart failure and cognitive impairment emerge as public health problems that need to be
addressed due to the aging global population. The conditions that often coexist are strongly …

Molecular mechanisms underlying the cardiovascular benefits of SGLT2i and GLP-1RA

DZ Khat, M Husain - Current diabetes reports, 2018 - Springer
Abstract Purpose of Review In addition to their effects on glycemic control, two specific
classes of relatively new anti-diabetic drugs, namely the sodium glucose co-transporter-2 …

Effects of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors on cardiorenal and metabolic outcomes in people without diabetes

AK Papazafiropoulou, A Melidonis… - Current …, 2021 - ingentaconnect.com
During the last decade, the results of large-scale, randomized, clinical trials on newer
antidiabetic agents, glucagon-like peptide-1 (GLP-1) receptor agonists and sodium glucose …

SGLT2 inhibitors vs. GLP-1 agonists to treat the heart, the kidneys and the brain

B Rolek, M Haber, M Gajewska, S Rogula… - Journal of …, 2023 - mdpi.com
Sodium glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like-peptide-1 receptor
(GLP-1-R) agonists are novel therapeutic agents used for the management of type 2 …

How glucagon-like peptide 1 receptor agonists work

CR Andreasen, A Andersen, FK Knop… - Endocrine …, 2021 - ec.bioscientifica.com
In recent years, glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become central
in the treatment of type 2 diabetes (T2D). In addition to their glucose-lowering properties with …

GLP-1 based therapeutics: simultaneously combating T2DM and obesity

KM Heppner, D Perez-Tilve - Frontiers in neuroscience, 2015 - frontiersin.org
Glucagon-like peptide-1 (GLP-1) enhances meal-related insulin secretion, which lowers
blood glucose excursions. In addition to its incretin action, GLP-1 acts on the GLP-1 receptor …

Spotlight on the human brain: central actions of SGLT2 inhibitors?

J Hummel, S Kullmann, M Heni - The Journal of Clinical …, 2022 - academic.oup.com
SGLT2 inhibitors (SGLT2is) have been developed to lower blood glucose. They were
subsequently found to be beneficial in other conditions that lead to the recent …