Immune imprinting describes how the first exposure to a virus shapes immunological
outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory …

The continuous emergence of highly immune evasive SARS-CoV-2 variants, like XBB. 1.51,
2 and XBB. 1.163, 4, highlights the need to update COVID-19 vaccine compositions …

Immunological memory is the key source of protective immunity against pathogens. At the
current stage of the COVID-19 pandemic, heterologous combinations of exposure to viral …

The continuing emergence of SARS-CoV-2 variants highlights the need to update COVID-19
vaccine compositions. However, immune imprinting induced by vaccination based on the …

Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …

Immune memory is tailored by cues that lymphocytes perceive during priming. The severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in …

To combat the evolving SARS-CoV-2 Omicron variants, bivalent COVID-19 mRNA vaccines,
encoding both ancestral and Omicron BA. 5 spikes, have replaced monovalent vaccines in …

The heterogeneity of the SARS-CoV-2 immune responses has become considerably more
complex over time and diverse immune imprinting is observed in vaccinated individuals …

RNA vaccines are efficient preventive measures to combat the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) pandemic. High levels of neutralizing SARS-CoV-2 …

During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been
deployed globally. We investigated whether antibodies stimulated by mRNA vaccination …