Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

CJ Reynolds, JM Gibbons, C Pade, KM Lin… - Science, 2022 - science.org
The impact of the initial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infecting strain on downstream immunity to heterologous variants of concern (VOCs) is …

Alarming COVID variants show vital role of genomic surveillance.

D Cyranoski - Nature, 2021 - go.gale.com
Alarming COVID variants show vital role of genomic surveillance. - Document - Gale OneFile:
Health and Medicine Use this link to get back to this page. Copy Skip to Content Library Menu …

An antibody-escape estimator for mutations to the SARS-CoV-2 receptor-binding domain

AJ Greaney, TN Starr, JD Bloom - Virus evolution, 2022 - academic.oup.com
A key goal of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surveillance
is to rapidly identify viral variants with mutations that reduce neutralization by polyclonal …

SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain

L Yurkovetskiy, KE Pascal, C Tomkins-Tinch, T Nyalile… - BioRxiv, 2020 - biorxiv.org
Virus genome sequence variants that appear over the course of an outbreak can be
exploited to map the trajectory of the virus from one susceptible host to another. While such …

Low genetic diversity may be an Achilles heel of SARS-CoV-2

JW Rausch, AA Capoferri… - Proceedings of the …, 2020 - National Acad Sciences
Scientists worldwide are racing to develop effective vaccines against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 …

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

L Liu, S Iketani, Y Guo, JFW Chan, M Wang, L Liu… - Nature, 2022 - nature.com
Abstract The B. 1.1. 529/Omicron variant of SARS-CoV-2 was only recently detected in
southern Africa, but its subsequent spread has been extensive, both regionally and globally …

SARS-CoV-2 variants and vaccines

PR Krause, TR Fleming, IM Longini… - … England Journal of …, 2021 - Mass Medical Soc
Viral variants of concern may emerge with dangerous resistance to the immunity generated
by the current vaccines to prevent coronavirus disease 2019 (Covid-19). Moreover, if some …

Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses

JA Tomalka, MS Suthar, SG Deeks, RP Sekaly - Nature Immunology, 2022 - nature.com
Host genetic and environmental factors including age, biological sex, diet, geographical
location, microbiome composition and metabolites converge to influence innate and …

SARS-CoV-2 spike D614G change enhances replication and transmission

B Zhou, TTN Thao, D Hoffmann, A Taddeo, N Ebert… - Nature, 2021 - nature.com
During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike
glycoprotein (S) has emerged; virus containing this substitution has become the …

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

AM Arvin, K Fink, MA Schmid, A Cathcart, R Spreafico… - Nature, 2020 - nature.com
Antibody-dependent enhancement (ADE) of disease is a general concern for the
development of vaccines and antibody therapies because the mechanisms that underlie …