There is growing evidence that vascular arginase plays a role in pathophysiology of
vascular diseases. We recently reported high arginase activity/expression in young adult …

There is a growing evidence that arginase has a role in the pathophysiology of
cardiovascular diseases including hypertension. We recently reported arginase …

Objective High vascular arginase activity and subsequent reduction in vascular nitric oxide
production were recently reported in animal models of hypertension. The present study …

Arginase upregulation is associated with aging and cardiovascular diseases. In this study
we report on the cardiovascular phenotype of the arginase II knockout (KO) mouse. We …

Aims Growing evidence suggests that arginase misregulation plays a key role in the
pathophysiology of essential hypertension. In the present study, we investigated the …

Objective A decrease in nitric oxide (NO) bioavailability has been proposed to contribute to
endothelial dysfunction and increased peripheral resistances during essential arterial …

Objective.–Arginase is a nitric oxide synthase-alternative pathway for l-arginine breakdown
leading to biosynthesis of urea and l-ornithine. Arginase pathway is inducible by …

Vascular tissues express arginase that metabolizes l-arginine to l-ornithine and urea and
thus reduces substrate availability for nitric oxide formation. Dahl salt-sensitive (Dahl-S) rats …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Increased arginase activity has been reported in a variety of disease conditions
characterized by vascular dysfunction. In the present study, the potentially protective effect of …