Arginase 1, via competing with nitric oxide (NO) synthase for the substrate l-arginine, may
interfere with NO-mediated vascular responses. We tested the hypothesis that arginase 1 …

OBJECTIVE: Alterations of wall shear stress can predispose the endothelium to the
development of atherosclerotic plaques. Ample evidence indicates that arginase expression …

Background Elevated arginase (Arg) activity is reported to be involved in diabetes-induced
vascular endothelial dysfunction. It can reduce L-arginine availability to nitric oxide (NO) …

Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells
(VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This …

Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction
plays an important role in various cardiovascular disorders, including atherosclerosis …

OBJECTIVE To determine 1) whether renal arginase activity or expression is increased in
diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN) …

Activated arginase has been implicated in many diseases including cancer, immune cell
dysfunction, infections, and vascular disease. Enhanced arginase activity has been reported …

Enhanced vascular arginase activity can impair endothelium-dependent vasorelaxation by
decreasing l-arginine availability to endothelial nitric oxide (NO) synthase, thereby reducing …

Oxidative stress and inflammation in the vascular wall are essential mechanisms of
atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …