Background and Purpose Emerging evidence suggests a selective up‐regulation of
arginase I in diabetes causing coronary artery disease; however, the mechanisms behind …

Abstract l-Arginine is the common substrate for nitric oxide synthases (NOS) and arginase.
Whereas the contribution of NOS to collateral artery growth (arteriogenesis) has been …

Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction
(VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is …

Previous studies have shown high arginase activity at inflammatory sites. Arginase convertsl-
arginine tol-ornithine, sharing a common substrate with nitric oxide synthase. It exists as two …

Aims Extrahepatic arginases are postulated to be involved in cardiovascular-related
pathologies by competing with nitric oxide synthase (NOS) for the common substrate l …

Arginase-2 counteracts endothelial nitric oxide synthase (eNOS) activity in human
endothelium, and its expression is negatively controlled by histone deacetylase (HDAC2) …

OBJECTIVES:(i) To characterize the polymorphism of arginase 1 (ARG1), a new candidate
gene in coronary heart disease (CHD), in the Algerian population;(ii) To evaluate the effect …

The present study was designed to investigate the roles of enhanced arginase activity due to
up-regulated arginases and the decreased hydroxyarginine for accelerating intimal …

Background and purpose: Arginase and nitric oxide (NO) synthase share the common
substrate L‐arginine, and arginase inhibition is proposed to increase NO production by …

INTRODUCTION: Acute arterial thrombosis causes endothelial dysfunction due to
decreased nitric oxide bioactivity. Increased arginase activity may modulate intracellular L …