Oxidized low-density lipoprotein (OxLDL) impairs NO signaling and endothelial function,
and contributes to the pathogenesis of atherosclerosis. Arginase reciprocally regulates NO …

In normotensive rats (NTR) and spontaneously hypertensive rats (SHR) with high (subgroup
1) and low (subgroup 2) level of the systemic arterial pressure (SAP) we studied an activity …

Arginine is a semi-essential amino acid that plays a critical role in several metabolic
pathways. The best known of these is as the immediate precursor of urea in the liver and to a …

Arginine metabolism plays a major role in cardiovascular physiology and pathophysiology,
largely via nitric oxide (NO)-dependent processes. It is becoming increasingly apparent …

Obesity is associated with development and progression of chronic kidney disease (CKD).
Recent evidence demonstrates that enhanced levels of the L-arginine: ureahydrolase …

Objective—Our laboratory has previously created 2 strains of rabbits with genetically
determined high-atherosclerotic response (HAR) and low-atherosclerotic response (LAR) …

Background Arginase competes with nitric oxide synthase for their common substrate L-
arginine. Up-regulation of arginase in coronary artery disease (CAD) and diabetes mellitus …

There is increasing evidence that upregulation of arginase contributes to impaired
endothelial function in aging. In this study, we demonstrate that arginase upregulation leads …

This special issue, entitled “the role of arginase in endothelial dysfunction,” assembles
original contributions (1–4), as well as timely reviews (5–12) broadly related to the …

Nitric oxide (NO) is crucial for maintaining normal endothelial function and vascular integrity.
Increased arginase activity in diabetes might compete with NO synthase (NOS) for their …