Age-related Changes in GABA: Effects on Neural Distinctiveness and Variability

PS Lalwani - 2022 - deepblue.lib.umich.edu
Tens of millions of otherwise healthy people experience age-related cognitive and sensory
impairments. Nevertheless, there are large individual differences in these declines and …

GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness

JD Chamberlain, H Gagnon, P Lalwani… - Neurobiology of …, 2021 - Elsevier
Age-related neural dedifferentiation—a decline in the distinctiveness of neural
representations in the aging brain—has been associated with age-related declines in …

Dynamic recovery: GABA agonism restores neural variability in older, poorer performing adults

P Lalwani, DD Garrett, TA Polk - Journal of Neuroscience, 2021 - Soc Neuroscience
Aging is associated with cognitive impairment, but there are large individual differences in
these declines. One neural measure that is lower in older adults and predicts these …

Neural distinctiveness declines with age in auditory cortex and is associated with auditory GABA levels

P Lalwani, H Gagnon, K Cassady, M Simmonite… - NeuroImage, 2019 - Elsevier
Neural activation patterns in the ventral visual cortex in response to different categories of
visual stimuli (eg, faces vs. houses) are less selective, or distinctive, in older adults than in …

Michigan Neural Distinctiveness (MiND) project: Investigating the scope, causes, and consequences of age-related neural dedifferentiation

H Gagnon, M Simmonite, K Cassady, JD Chamberlain… - BioRxiv, 2018 - biorxiv.org
Background Aging is often associated with behavioral impairments, but some people age
more gracefully than others. Why? One factor that may play a role is individual differences in …

Occipital GABA levels in older adults and their relationship to visual perceptual suppression

K Pitchaimuthu, Q Wu, O Carter, BN Nguyen, S Ahn… - Scientific Reports, 2017 - nature.com
Several studies have attributed certain visual perceptual alterations in older adults to a likely
decrease in GABA (Gamma Aminobutyric Acid) concentration in visual cortex, an …

Michigan Neural Distinctiveness (MiND) study protocol: investigating the scope, causes, and consequences of age-related neural dedifferentiation

H Gagnon, M Simmonite, K Cassady, J Chamberlain… - BMC neurology, 2019 - Springer
Background Aging is often associated with behavioral impairments, but some people age
more gracefully than others. Why? One factor that may play a role is individual differences in …

GABA Levels Decline with Age: A Longitudinal Study

MD Zuppichini, AM Hamlin, Q Zhou, E Kim… - Imaging …, 2024 - direct.mit.edu
One factor that might contribute to functional deterioration in healthy older adults is a decline
in the brain's major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). Previous …

Frontal gamma-aminobutyric acid concentrations are associated with cognitive performance in older adults

EC Porges, AJ Woods, RAE Edden, NAJ Puts… - Biological psychiatry …, 2017 - Elsevier
Background Gamma-aminobutyric acid (GABA), the brain's principal inhibitory
neurotransmitter, has been associated with perceptual and attentional functioning. Recent …

19 Exploring GABA Concentration Changes in Sensorimotor Cortex in Older Adults During Motor & Cognitive Performance

G Champion, LC Krishnamurthy, JR Nocera… - Journal of the …, 2023 - cambridge.org
Objective: Aging is associated with changes in cortical excitability which may affect motor
learning and cognitive function via selective modulation of gamma aminobutyric acid …