Background Arginase is implicated in the pathogenesis behind endothelial dysfunction in
type 2 diabetes mellitus (T2 DM) by its inhibition of nitric oxide formation. Strict glycaemic …

Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …

Objectives: The development of microvascular complications in diabetes is a complex
process in which endothelial dysfunction is important. Emerging evidence suggests that …

Background: Endothelial dysfunction contributes to the development of vascular
complication in diabetes. Arginase has emerged as a key mechanism behind endothelial …

Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …

Background Arginase competes with nitric oxide synthase for their common substrate L-
arginine. Up-regulation of arginase in coronary artery disease (CAD) and diabetes mellitus …

OBJECTIVE—Diabetes, arterial hypertension, hypercholesterolemia, and aging are
associated with endothelial dysfunction in various vasculatures. Endothelium-dependent …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

OBJECTIVE The endothelium plays a pivotal role in the regulation of vascular tone by
releasing nitric oxide (NO). Increased availability of L-arginine, the natural precursor of NO …

Type 2 diabetes mellitus (T2DM) is becoming a major contributor to cardiovascular disease.
One of the early signs of T2DM associated cardiovascular events is the development of …