[HTML][HTML] Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
[HTML][HTML] The EWAS Catalog: a database of epigenome-wide association studies
Epigenome-wide association studies (EWAS) seek to quantify associations between
traits/exposures and DNA methylation measured at thousands or millions of CpG sites …
traits/exposures and DNA methylation measured at thousands or millions of CpG sites …
Epigenome-wide association studies for common human diseases
VK Rakyan, TA Down, DJ Balding, S Beck - Nature Reviews Genetics, 2011 - nature.com
Despite the success of genome-wide association studies (GWASs) in identifying loci
associated with common diseases, a substantial proportion of the causality remains …
associated with common diseases, a substantial proportion of the causality remains …
[HTML][HTML] Association of DNA methylation with age, gender, and smoking in an Arab population
SB Zaghlool, M Al-Shafai, WA Al Muftah, P Kumar… - Clinical …, 2015 - Springer
Background Modification of DNA by methylation of cytosines at CpG dinucleotides is a
widespread phenomenon that leads to changes in gene expression, thereby influencing and …
widespread phenomenon that leads to changes in gene expression, thereby influencing and …
[HTML][HTML] Accounting for cellular heterogeneity is critical in epigenome-wide association studies
AE Jaffe, RA Irizarry - Genome biology, 2014 - Springer
Background Epigenome-wide association studies of human disease and other quantitative
traits are becoming increasingly common. A series of papers reporting age-related changes …
traits are becoming increasingly common. A series of papers reporting age-related changes …
EWAS Data Hub: a resource of DNA methylation array data and metadata
Abstract Epigenome-Wide Association Study (EWAS) has become an effective strategy to
explore epigenetic basis of complex traits. Over the past decade, a large amount of …
explore epigenetic basis of complex traits. Over the past decade, a large amount of …
Epigenome-wide association studies (EWAS): past, present, and future
JM Flanagan - … Risk Assessment, Diagnosis, Treatment, and Prognosis, 2015 - Springer
Just as genome-wide association studies (GWAS) grew from the field of genetic
epidemiology, so too do epigenome-wide association studies (EWAS) derive from the …
epidemiology, so too do epigenome-wide association studies (EWAS) derive from the …
[HTML][HTML] eFORGE: a tool for identifying cell type-specific signal in epigenomic data
Epigenome-wide association studies (EWAS) provide an alternative approach for studying
human disease through consideration of non-genetic variants such as altered DNA …
human disease through consideration of non-genetic variants such as altered DNA …
EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study
Abstract Epigenome-Wide Association Study (EWAS) has become a standard strategy to
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …
[HTML][HTML] Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA methylation differences associated with complex phenotypes. Many of the challenges …