Pleiotropic genomic variants at 17q21. 31 associated with bone mineral density and body fat mass: a bivariate genome-wide association analysis

XT Wei, GJ Feng, H Zhang, Q Xu, JJ Ni… - European Journal of …, 2021 - nature.com
Osteoporosis and obesity are two severe complex diseases threatening public health
worldwide. Both diseases are under strong genetic determinants as well as genetically …

[HTML][HTML] Bivariate genome-wide association analysis identified three pleiotropic loci underlying osteoporosis and obesity

YF Pei, XT Wei, GJ Feng, H Zhang, XL Yang… - Clinical …, 2020 - ncbi.nlm.nih.gov
Osteoporosis and obesity are two inheritable diseases indexed by low bone mineral density
(BMD) and high body mass index (BMI), and are correlated. Osteoblast cells and adipocyte …

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity

L Liu, XL Yang, H Zhang, ZJ Zhang, XT Wei, GJ Feng… - Human genetics, 2020 - Springer
Aiming to uncover a shared genetic basis of abdominal obesity and osteoporosis, we
performed a bivariate GWAS meta-analysis of femoral neck BMD (FNK-BMD) and trunk fat …

Pleiotropic loci underlying bone mineral density and bone size identified by a bivariate genome-wide association analysis

H Zhang, L Liu, JJ Ni, XT Wei, GJ Feng, XL Yang… - Osteoporosis …, 2020 - Springer
Aiming to identify pleiotropic genomic loci for bone mineral density and bone size, we
performed a bivariate GWAS in five discovery samples and replicated in two large-scale …

Association of 3q13. 32 variants with hip trochanter and intertrochanter bone mineral density identified by a genome-wide association study

YF Pei, ZG Xie, XY Wang, WZ Hu, LB Li, S Ran… - Osteoporosis …, 2016 - Springer
We performed a GWAS of trochanter and intertrochanter bone mineral density (BMD) in the
Framingham Heart Study and replicated in three independent studies. Our results identified …

Joint study of two genome-wide association meta-analyses identified 20p12. 1 and 20q13. 33 for bone mineral density

YF Pei, WZ Hu, MW Yan, CW Li, L Liu, XL Yang, R Hai… - Bone, 2018 - Elsevier
In the present study, aiming to identify loci associated with osteoporosis, we conducted a
joint association study of 2 independent genome-wide association meta-analyses of femoral …

A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis

ZH Tang, P Xiao, SF Lei, FY Deng… - The Journal of …, 2007 - academic.oup.com
Context: A genome-wide bivariate analysis was conducted for body fat mass (BFM) and
bone mineral density (BMD) in a large Caucasian sample. We found some quantitative trait …

Genome-wide association meta-analyses identified 1q43 and 2q32. 2 for hip Ward's triangle areal bone mineral density

YF Pei, WZ Hu, R Hai, XY Wang, S Ran, Y Lin, H Shen… - Bone, 2016 - Elsevier
Aiming to identify genomic variants associated with osteoporosis, we performed a genome-
wide association meta-analysis of bone mineral density (BMD) at Ward's triangle of the hip …

[HTML][HTML] An osteoporosis risk SNP at 1p36. 12 acts as an allele-specific enhancer to modulate LINC00339 expression via long-range loop formation

XF Chen, DL Zhu, M Yang, WX Hu, YY Duan… - The American Journal of …, 2018 - cell.com
Genome-wide association studies (GWASs) have reproducibly associated variants within
intergenic regions of 1p36. 12 locus with osteoporosis, but the functional roles underlying …

Identification of novel potentially pleiotropic variants associated with osteoporosis and obesity using the cFDR method

Y Hu, LJ Tan, XD Chen, Z Liu, SS Min… - The Journal of …, 2018 - academic.oup.com
Context Genome-wide association studies (GWASs) have been successful in identifying loci
associated with osteoporosis and obesity. However, the findings explain only a small …