Antiplatelet therapy in cardiovascular disease: Current status and future directions

G Passacquale, P Sharma, D Perera… - British Journal of …, 2022 - Wiley Online Library
Antiplatelet medications remain a cornerstone of therapy for atherosclerotic cardiovascular
and cerebrovascular diseases. In primary prevention (patients with cardiovascular risk …

Antiplatelet therapy: new pharmacological agents and changing paradigms

D Capodanno, JL Ferreiro… - Journal of Thrombosis …, 2013 - Wiley Online Library
Recurrent atherothrombotic events in patients with acute coronary syndromes (ACS) and/or
those undergoing percutaneous coronary intervention (PCI) are essentially platelet‐driven …

Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future

NC Raju, JW Eikelboom, J Hirsh - Nature Clinical Practice …, 2008 - nature.com
Aspirin is the foundation antiplatelet therapy for patients at risk of cardiovascular events. The
thienopyridine, clopidogrel, is modestly more effective than aspirin and in patients with …

Antiplatelet drugs: which targets for which treatments?

C Gachet - Journal of Thrombosis and Haemostasis, 2015 - Wiley Online Library
The current standard care for acute coronary syndromes is dual antiplatelet therapy
combining the COX1 inhibitor aspirin with a drug targeting the P2Y12 receptor, together with …

New directions in antiplatelet therapy

JL Ferreiro, DJ Angiolillo - Circulation: cardiovascular interventions, 2012 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory process that is known to be the underlying cause
of coronary artery disease (CAD). 1 In addition to being the first step of primary hemostasis …

Oral antiplatelet therapy for atherothrombotic disease: overview of current and emerging treatment options

DJ Fintel - Vascular health and risk management, 2012 - Taylor & Francis
Clinical presentations of atherothrombotic vascular disease, such as acute coronary
syndromes, ischemic stroke or transient ischemic attack, and symptomatic peripheral arterial …

Advances in antiplatelet therapy: agents in clinical development

DJ Angiolillo, DL Bhatt, PA Gurbel… - The American journal of …, 2009 - Elsevier
Antiplatelet agents are the cornerstone of treatment for patients with acute coronary
syndromes and patients undergoing percutaneous coronary intervention. The current “gold …

Clinical evidence for oral antiplatelet therapy in acute coronary syndromes

SD Wiviott, PG Steg - The Lancet, 2015 - thelancet.com
Platelet-mediated thrombosis is a major pathophysiological mechanism that underlies acute
coronary syndromes, and therefore, antiplatelet therapy is an important foundation in the …

Antiplatelet drugs: what comes next?

AA Kei, M Florentin, DP Mikhailidis… - Clinical and Applied …, 2011 - journals.sagepub.com
Antiplatelet drugs are important components in the management of atherothrombotic
vascular disease. However, several limitations restrict the safety and efficacy of current …

Long-term treatment with the combination of rivaroxaban and aspirin in patients with chronic coronary or peripheral artery disease: outcomes during the open label …

JW Eikelboom, J Bosch, SJ Connolly… - European Heart …, 2022 - academic.oup.com
Aims To describe outcomes of patients with chronic coronary artery disease (CAD) and/or
peripheral artery disease (PAD) enrolled in the Cardiovascular Outcomes for People Using …