Background Age at natural menopause (ANM) is an important index for women's health.
Either early or late ANM is associated with a series of adverse outcomes later in life. Despite …

Menopause is not only the end of reproductive life, it is also related to diseases such as
hyperlipidaemia, atherosclerotic cardiovascular disease, osteoporosis and breast cancer …

Background Age at natural menopause (ANM) is a complex trait with high heritability and is
associated with several major hormonal-related diseases. Recently, several genome-wide …

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …

Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high
heritability. Abnormal timing of menarche or menopause is associated with a reduced span …

Current knowledge of the genetic architecture of key reproductive events across the female
life course is largely based on association studies of European descent women. The …

Objective: To identify novel susceptibility genes for age at natural menopause (ANM).
Methods: Using transcription data generated in tissues from normal hypothalami (n= 73) and …

Genome-wide association studies (GWAS) have been successful in uncovering genetic
determinants of age at menarche and age at natural menopause. To date, more than 30 …

Early menopause (EM) affects up to 10% of the female population, reducing reproductive
lifespan considerably. Currently, it constitutes the leading cause of infertility in the western …

In recent years, common genetic variants have been identified by genome-wide association
studies (GWASs) that have led to the detection of 44 genetic loci associated with …