It is known that genetic risk factors contribute to the formation of calcium-based kidney
stones. The majority of calcium is reabsorbed via paracellular transport through tight …

Background: Genetic risk factors contribute to the formation of calcium-based kidney stones.
The majority of calcium is reabsorbed via paracellular transport through tight junctions along …

Kidney stones contain calcium crystals that precipitate out of the urine and then aggregate to
form stones. This causes severe discomfort to the patient and can damage the kidneys …

The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence
implicates a role for defective calcium reabsorption in the renal proximal tubule. We …

Claudins are tight junction proteins that regulate the paracellular transport of solutes across
epithelial layers. New findings demonstrate a role for the cation-selective protein claudin 2 in …

Paracellular transport in the kidney is mediated by a family of proteins located in the tight
junctions called claudins which confers its ionic selectivity. Claudin-2 is highly expressed in …

Claudins are tight-junction membrane proteins that function as both pores and barriers in the
paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability …

Claudins are tight-junction membrane proteins that function as both pores and barriers in the
paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability …

Refers to: Curry JN, Saurette M, Askari M, Pei L, Filla MB, Beggs MR, Rowe PS, Fields T,
Sommer AJ, Tanikawa C, Kamatani Y, Evan AP, Totonchi M, Alexander RT, Matsuda K, Yu …

Idiopathic hypercalciuria is the major risk factor for kidney stone disease. Constitutive global
knockout in mice of claudin‐2 (Cldn2), which encodes a paracellular cation channel …