The β-hematin formation is a unique process adopted by Plasmodium sp. to detoxify free
heme and represents a validated target to design new effective antimalarials. Most of the β …

In a previous study, target based screening was carried out for inhibitors of β-hematin
(synthetic hemozoin) formation, and a series of triarylimidazoles were identified as active …

A versatile approach to control crystallization involves the use of modifiers, which are
additives that interact with crystal surfaces and alter their growth rates. Elucidating a …

Based on the idea that compounds designed to exhibit high affinity for heme would block
hemozoin formation, a critical heme-detoxification process for malarial parasites, we …

The emergence of drug resistant strains of Plasmodium spp. creates a critical need for the
development of novel antimalarials. Formation of hemozoin, a crystalline heme …

A series of heterocyclic chloroquine hybrids containing either a β-phenethylamine fragment
or a 2-aminoindane moiety were synthesized and screened in vitro as inhibitors of β …

Malaria is a preventable and curable disease known to be caused by the parasitic infection
of Plasmodium spp., which is transmitted through the bites of infected female Anopheles …

In this study, we investigated a series of triarylimidazoles, in an effort to elucidate critical
SAR information pertaining to their anti-plasmodial and β-hematin inhibitory activity. Our …

Abstract The Malaria Box, assembled by the Medicines for Malaria Venture, is a set of 400
structurally diverse, commercially available compounds with demonstrated activity against …

Conspectus Over the last century, malaria deaths have decreased by more than 85%.
Nonetheless, there were 405 000 deaths in 2018, mostly resulting from Plasmodium …