The major protective immune response against viruses is production of type I and III
interferons (IFNs). IFNs induce the expression of hundreds of IFN-stimulated genes (ISGs) …

Interferons (IFN) are an assemblage of signaling proteins made and released by various
host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV) …

Abstract Type I (-α, β) and type III (-λ) interferons (IFNs) are produced in response to virus
infection and upregulate a largely overlapping set of IFN stimulated genes which mediate …

Host factors restricting the transmission of respiratory viruses are poorly characterized. We
analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which …

Asthma is a chronic respiratory disease affecting people of all ages, especially children,
worldwide. Origins of asthma are suggested to be placed in early life with heterogeneous …

Innate antiviral responses in bronchial epithelial cells (BECs) provide the first line of defense
against respiratory viral infection and the effectiveness of this response is critically …

As an innate immune response against diverse viral infections, a host induces two types of
interferon (IFN), type-I (IFN-β/α) and type-III (IFN-λ). We investigated IFN inductions by …

Interferons (IFN) are crucial for the innate immune response. Slightly more than two decades
ago, a new type of IFN was discovered: the lambda IFN (type III IFN). Like other IFN, the type …

The spread of acute respiratory viral infections is controlled by type I and III interferon (IFN)
signaling. While the mechanisms of type I IFN signaling have been studied in detail, features …

The type I alpha/beta interferons (IFN-α/β) are known to play an important role in host
defense against influenza A virus infection, but we have now discovered that the recently …