Objective.–Arginase is a nitric oxide synthase-alternative pathway for l-arginine breakdown
leading to biosynthesis of urea and l-ornithine. Arginase pathway is inducible by …

Arginase shares a common substrate, L‐arginine, with nitric oxide (NO) synthase (NOS). It is
thought that arginase, if it is expressed in the endothelium, might play a pivotal role in the …

There is growing evidence that vascular arginase plays a role in pathophysiology of
vascular diseases. We recently reported high arginase activity/expression in young adult …

ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR
FUNCTION - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Endothelial cells (EC) metabolize l-arginine mainly by arginase, which exists as two distinct
isoforms, arginase I and II. To understand the roles of arginase isoforms in EC arginine …

SUMMARY 1 Nitric oxide (NO) plays a fundamental role in the vasculature because of its
diverse influence in vascular protection, including its well‐reported antiproliferative, anti …

Polyamines are essential for cell proliferation; therefore, we hypothesized that arginase I or
arginase II activities, via production of ornithine for polyamine synthesis, may be limiting for …

Arginase metabolizes the semi-essential amino acid l-arginine to l-ornithine and urea. There
are two distinct isoforms of arginase, arginase I and II, which are encoded by separate …

Activated arginase has been implicated in many diseases including cancer, immune cell
dysfunction, infections, and vascular disease. Enhanced arginase activity has been reported …

Rat aortic endothelial cells were found to contain both constitutive and lipopolysaccharide
(LPS)-inducible arginase activity. Studies were performed to determine whether induction of …